Dev Cell: Cancer patients are saved by the latest study in the United States! A fatty acid can kill human cancer cells!

!---- Introduction: In medicine, cancer is a malignant tumor that originates in epithelial tissue, which is the most common type of malignant tumorwhat is commonly referred to as "cancer" is commonly referred to as all malignant tumorscancer has biological characteristics such as cell differentiation and proliferation abnormality, loss of growth, immersion and metastasiscancer treatment has always been a worldwide problemrecently, researchers at Washington State University have confirmed that a fatty acid called dioxylinamide (DGLA) can kill human cancer cellsthe study, published in the journal Developmental Cell, found that DGLA induces iron death in animal models and in actual human cancer cellsiron death is a kind of iron-dependent cell death found in recent years, because it is closely related to many disease processes, has become a hot topic of disease research"This finding has many implications, including a step toward potential treatments for cancer," said Jennifer Watts, an associate professor at Washington State Universityand the study's lead authorIf you can deliver DGLA accurately to cancer cells, it can promote iron death and lead to cancer cell deathjust by understanding the effects of this fat on iron death may also affect our perception of kidney disease and neurodegenerative diseases, in which case we want to prevent this type of cell death" Illustrated Abstract DGLA is a polyunsaturated fatty acid that is very small in the human body and very rare in the human dietCompared with other fatty acids (fatty acids in fish oil), DGLA's research is relatively inadequateWatts has studied diets, including DGLA, for nearly 20 years, using nematodes as animal models, and the scary nematode is a tiny worm that, because it is transparent, can easily study cell-level activity throughout the animal's relatively short life cycle and is often used in molecular researchresults found in beautiful hidden nematode cells can also often be transferred to human cellsWatts' team found that feeding nematodes with DGLA-rich bacteria kills all the germ cells in the nematode and the stem cells that make them, and that the way cells die is many signs of iron death"Many of the mechanisms we see in online worms are consistent with the characteristics of iron death in mammalian systems, including redox active iron and irreversible lipids, similar to molecular executioners," said Marcos Perez, a doctoral student at Washington State University and lead author of the study, "To find out if these findings will apply to human cells, Watts and Perez worked with Scott Dixon of Stanford University, who has been studying iron death and its potential to treat cancer for years," based on research on nematodes, the researchers found that DGLA induces iron death in human cancer cells they also found that one interacts with another fatty acid called ether lipids, which protect DGLA when the researchers removed ether lipids, cells died faster in the presence of DGLA in addition to these findings, the researchers have confirmed that the beautiful hidden nematode sydle nematode seisluds can be a useful animal model for studying iron death is used to study the field of iron death, which relies heavily on bacterial culture to keep the study going, Watts' team recently received a $1.4 million grant from the National Institutes of Health to study what makes nematode reproductive cells so sensitive to DGLA, as well as the role of mitochondria, the cells involved in fat burning and regulating metabolism, in iron death