Diabetes: Good news! Vitamin D or a cure for diabetes!

April 5, 2020 / / -- Maintaining vitamin D subject (VDR) levels in islet cells (beta cells) that synthesize and secrete insulin may help prevent the development of diabetes and counteract the progression of diseases caused by pancreatic cell damage.
the study, conducted by researchers at CIBER Diabetes and Related Metabolic Diseases (CIBERDEM) at the Autonomous University of Barcelona (UAB), suggests that the subject is a potential therapeutic target for the prevention and treatment of the disease.
: Vitamin D deficiency is associated with a high incidence of type 1 (T1D) and type 2 (T2D) diabetes, and researchers have also found a relationship between the disease and genetic mutations in vitamin D subjects.
, however, the specific participation of this vitamin in the development of the disease, especially in beta cells, remains unknown.
this is why the new study focuses on understanding the role of VDR in diabetes development by analyzing its behavior in mice.
of islet VDR expression in mice with type 1 and type 2 diabetes was reduced in patients with type 1 and type 2 diabetes.
addition, they have demonstrated that excessive VDR of beta cells in diabetic mice can alleviate disease, and that persistent levels of vitamin D in these cells protect their quality and function and prevent diabetes.
these results show that maintaining VDR expressions can basically counteract beta cell damage and prevent disease development.
The continued level of VDR prevents genetically modified mice from developing severe hyperglycemia, partially protecting the quality of beta cells, thereby reducing local inflammation and diabetes," said Alba Casellas, a researcher at CIBERDEM's Center for Animal Biotechnology and Gene Therapy (CBATEG).
all of this reveals the unprecedented role of vitamin D lithums in the pathophysiology of diabetes.
glucose stimulating vitamin D subjects also confirmed a negative correlation between the expression of VDR and circulating sugar levels.
, we found that when glucose levels in the blood were at physiologically low levels, such as fasting, vitamin D subjects were reduced.
linked the results to the characteristics of pancreatic cells in diabetics, the researchers found that "these results can be interpreted as being associated with low glucose levels in the cells."
" role in the treatment of diabetes Although the benefits of vitamin D supplementation as a method of preventing diabetes have been widely reported, clinical data on its improvement in diabetes status are controversial.
"differences in the effectiveness of vitamin D supplements may be due to negative regulation of VDR during diabetes," Dr Casellas noted in response to these results.
, the authors suggest that, in order to achieve positive results, a dose of vitamin D supplementation must be arranged in the event of a decrease in VDR expression.
, future diabetes treatment strategies should be based on a better understanding of the mechanisms of negative regulation of VDR during diabetes and focus on restoring VDR levels," they concluded.
() References: 1: New therapeutic strategy against diabetes: Vitamin D D 2 Meritxell Morró et al Vitamin D Receptor overexpression in beta-cells ameliorates diabetes in mice, Diabetes (2020). DOI: 10.2337/db19-0757.