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Diabetes Obes Metab: Effects of dipeptidyl peptidase 4 inhibitors and sulfonylureas on the cognition and physical function of nursing home residents

 Last Update: 2021-11-01
 Source: Internet
 Author: User

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Compared with sulfonylureas (SU), dipeptidyl peptidase 4 inhibitors (DPP4Is) can alleviate the decline in cognitive and physical function induced by hypoglycemia , but they are not available in the elderly, especially in nursing homes (NH) residents.
Comparative research
.

Hypoglycemia

Recently, a research article was published in Diabetes Obesity & Metabolism, an authoritative journal in the field of metabolic endocrine diseases.
Researchers aimed to evaluate the effects of DPP4Is and SUs on the cognitive and physical functions of NH residents
.

This new user cohort study included NH residents ≥65 years of age with clinical assessment and related medical insurance claims in the United States National Minimum Data Set (MDS) during the period 2007-2010
.

The researchers assessed the cognitive decline of the validated 6-point MDS Cognitive Performance Scale, the functional decline of the validated 28-point MDS Activity of Daily Living Scale, and hospitalization or emergency visits due to changes in mental status caused by medical insurance claims

The mean (SD) age of subjects in the matched cohort (N=1784) was 80 (8) years, and 73% were female
.

Before treatment started, approximately 46% of subjects had no or mild cognitive impairment, and 35% of subjects had no or mild dysfunction

It can be seen that compared with SU, the cognitive and functional decline rate of elderly NH residents using DPP4Is may be reduced, but large studies with greater statistical power should solve the remaining uncertainties by providing more accurate effect estimates
.

Compared with SU, the cognitive and functional decline rate of elderly NH residents using DPP4Is may be reduced, but large-scale studies with greater statistical power should solve the remaining uncertainties by providing more accurate effect estimates
.
Original Source: Effects of Dipeptidyl Peptidase-4 Inhibitors and Sulfonylureas ON Cognitive and Physical Function in Nursing Home The Residents in this message

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