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Original title: Diet structure should pay attention to prevent cancer "find you"
"sick from the mouth", eat wrong, or even eat too much, may "eat out of the way". Reporters from Sun Yat-sen University affiliated with the Sixth Hospital was informed that the hospital Professor Li Menghong team found that the key gene of tumor cancer process ILF3 can promote tumor cells to ingest a large number of surrounding nutrients, thereby malignant proliferation. As a result, excessive nutrient intake, especially foods rich in serine and methionine, is more likely to cause cancer, and the findings promise new ideas for bowel cancer treatment.
On November 26th, Professor Li Menghong of Sun Yat-sen University's Sixth Hospital published an article in cell Research, which found that the serine synthesis pathline can be overactivated by ILF3 to provide energy supply, nucleotide synthesis raw materials and reducing force to cells, inhibit oxidative stress, and promote malignant growth of tumor cells.
a key gene in the process of cancerous tumors caused by ILF3. This study reveals for the first time the key role and regulatory mechanism of mRNA binding protein ILF3 in maintaining the metabolism of serine in colorectal cancer cells, promoting the progression of colorectal cancer malignancy, and proves through in vivo and in vivo experiments that ILF3 can be used as a new prognostic predictor and potential therapeutic target for colorectal cancer, and its inhibitors have potential drug development value and have been patented in China. Li Menghong's team analyzed upstream, and the gene may have been a factor in the resistance to the first-line drug for bowel cancer. Targeting this gene and downstream metabolic path paths may provide new thinking for future solutions to sytoxidoxe resistance.
colorectal cancer is the world's third-high incidence of malignant tumors. In recent years, the incidence of colorectal cancer has been increasing year by year in China. Li Menghong introduced that the pathogenesis of colorectal cancer is complex, the course of the disease is long, and needs to be observed in many links. Sitoxy monoantigen has good effect and reactivity to a subsexual bowel cancer, however, some people still have invalidation of sitoxysi monoantigen. Starting from the clinic, the key gene ILF3 of tumor cancer process was identified by large histological methods such as sequencing. The key gene, ILF3, can promote the malignant proliferation of tumors by promoting the greedy intake of surrounding nutrients, especially glucose, serine, etc., for tumor cells.
intake of nutrients, especially foods rich in serine and methionine, has been reported to promote cancer and development. Nowadays, people's diet structure is more high in fat and high in protein, more likely to induce cancer. Li Menghong suggested that eating more fruits and vegetables and eating less meat can effectively prevent the occurrence of tumors.
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