Differences between stromal cell subpopulations

Lymph nodes are critical sites of the immune response, and lymph node stromal cells are essential

They describe a subset of lymph node cells that demonstrate that CD41⁺ mouse lymph node cells primarily express stromal cell and mast cell surface marker molecules

In this study, the scientists conducted an in-depth analysis of non-traditional stromal cells in the lymph node stromal and found two different stromal cell subsets CD41+ (platelet surface membrane protein integrin), Lyve1+ (lymphoendothelial receptor), and CD41⁺ Lyve1^-

DAI Li, the paper's first author, said: "This subset has also been found in human lymph nodes

On the other hand, the CD41+ Lyve1⁺ cell subset is mainly present in the lymphatic fluid of the thoracic duct and circulates throughout the body to replenish the subpopulation

This study further confirms that different stromal cell subsets within the lymph nodes have a clear functional division of labor, thereby ensuring the integrity and coordination of the entire lymph node function

Characterization of CD41+ cells in the lymph node