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The progress bar in 2021 has passed 40%, but the global new crown epidemic is far from stopping.
The tragic sight of India in the last month reminds the world that if you don’t be more vigilant and get vaccinated faster , The WHO's warning that "more people will die in the second year of the epidemic" is by no means alarmist.
And many people are still worried about another question: even if this epidemic is controlled by vaccination, how far are we from the next pandemic? Does the whole mankind know how many more viruses may change the face of the world forever, and where are they? The latest study published in Clinical Infectious Diseases proves the conjecture of many experts and scholars: the cross-species transmission of coronavirus from other animals to humans may be happening all the time, or it may be the next pandemic.
The fuse! Wearing a mask on the entire planet does not necessarily work.
.
.
This study comes from a team from Duke University in the United States.
They re-examined samples of 301 hospitalized pneumonia patients in Malaysia from 2017 to 2018 and detected one patient.
The canine-feline recombinant α-coronavirus, tentatively named CCoV-HuPn-2018, can exhibit cytopathic effects (CPE) in cell experiments.
Although this is a study on old samples, it is not yet possible to prove how dangerous this virus is, but if CCoV-HuPn-2018 can indeed cause disease in humans, then it is the eighth coronavirus with this ability.
.
The monitoring of potential pathogens in nature should really be on the agenda [1].
The origin of the new coronavirus is still a mystery.
The scientific community still mainly supports the hypothesis of human transmission from animals such as bats.
After all, viruses such as HIV and Ebola that pose a huge threat to humans at that time also originated from animals in central and western Africa.
Then spread across species.The Duke University team placed the research site in Malaysia because various farms and jungles in Southeast Asia are ideal places for bats that carry a large number of viruses to spread the virus.
Countries such as Cambodia have found that they are different from the new crown virus, but the degree is similar.
More than 90% of coronaviruses [2].
Bats are really the corresponding author of the mobile virus database research.
Professor Gregory Gray of Duke University said that he guessed at the beginning of the epidemic that there may be other coronaviruses that can infect humans and cause disease, but nucleic acid testing reagents can only detect one type.
Pathogens, so he asked his students to develop a new PCR detection method that can detect various previously unknown coronaviruses.
The first batch of samples tested came from Sarawak, East Malaysia.
Most of the patients were children living in the countryside with a history of frequent contact with poultry, livestock and wild animals.
In the samples of 8 patients, the research team found a previously unseen canine coronavirus (CCoV).
The first reaction of the research team was that the test was wrong, because there has never been a report of canine coronavirus infecting humans before, so Gregory Gray sent the test samples to Ohio State University, but the results of the test again showed that they were correct.
This is indeed the case.
A virus that can infect humans.
Two of the eight samples had a high CCoV content, which was sufficient for further experiments.
One of the samples showed obvious cytopathic effects when infected with dog tumor cells (A72).
But if you want to prove that it can cause disease in humans, you have to inject the virus directly into people.
This obviously cannot pass the ethical barrier.
The research team performed a complete genome sequencing of the CCoV-HuPn-2018 virus and found that it has the highest homology with another known CCoV, namely CCoV TN-449, but the S protein S2 subunit is similar to the cat coronavirus (FCoV).
) The homology of WSU 79-1683 is as high as 97%, which proves that this is a canine-feline recombinant coronavirus. In fact, CCoV-HuPn-2018 has a high degree of homology, and there are other viruses.
Further analysis also shows that CCoV-HuPn-2018 has a specific deletion in the middle part of the N protein (aa-12), which can infect humans, The more dangerous SARS virus (SARS-CoV) and the new coronavirus also have such N protein changes, indicating that CCoV-HuPn-2018 may really be able to be transmitted directly from animals to humans.
Among the seven human-causing coronaviruses previously discovered by humans, four of them only cause general cold symptoms, and then SARS, new coronaviruses and Middle East respiratory syndrome virus (MERS-CoV).
The research team will continue to expand the scope of sample testing in the future to see if there is more evidence that CCoV-HuPn-2018 causes human illness.
Professor Gregory Gray said in a report in "Science" that "the spread of viruses from animals to humans is a long process, not as scary as in movies" [3], so humans still have time to establish pathogens in animals in hotspots.
However, Singularity is really afraid that “human beings cannot learn any lessons from history”.
References: 1.
Vlasova AN, Diaz A, Damtie D, et al.
Novel Canine Coronavirus Isolated from a Hospitalized Pneumonia Patient, East Malaysia[J].
Clinical Infectious Diseases, 2021.
2.
/10.
1101/2021.
01.
26.
428212v1.
full3.
header image source: Pixabay Author of this article | Tan large
The tragic sight of India in the last month reminds the world that if you don’t be more vigilant and get vaccinated faster , The WHO's warning that "more people will die in the second year of the epidemic" is by no means alarmist.
And many people are still worried about another question: even if this epidemic is controlled by vaccination, how far are we from the next pandemic? Does the whole mankind know how many more viruses may change the face of the world forever, and where are they? The latest study published in Clinical Infectious Diseases proves the conjecture of many experts and scholars: the cross-species transmission of coronavirus from other animals to humans may be happening all the time, or it may be the next pandemic.
The fuse! Wearing a mask on the entire planet does not necessarily work.
.
.
This study comes from a team from Duke University in the United States.
They re-examined samples of 301 hospitalized pneumonia patients in Malaysia from 2017 to 2018 and detected one patient.
The canine-feline recombinant α-coronavirus, tentatively named CCoV-HuPn-2018, can exhibit cytopathic effects (CPE) in cell experiments.
Although this is a study on old samples, it is not yet possible to prove how dangerous this virus is, but if CCoV-HuPn-2018 can indeed cause disease in humans, then it is the eighth coronavirus with this ability.
.
The monitoring of potential pathogens in nature should really be on the agenda [1].
The origin of the new coronavirus is still a mystery.
The scientific community still mainly supports the hypothesis of human transmission from animals such as bats.
After all, viruses such as HIV and Ebola that pose a huge threat to humans at that time also originated from animals in central and western Africa.
Then spread across species.The Duke University team placed the research site in Malaysia because various farms and jungles in Southeast Asia are ideal places for bats that carry a large number of viruses to spread the virus.
Countries such as Cambodia have found that they are different from the new crown virus, but the degree is similar.
More than 90% of coronaviruses [2].
Bats are really the corresponding author of the mobile virus database research.
Professor Gregory Gray of Duke University said that he guessed at the beginning of the epidemic that there may be other coronaviruses that can infect humans and cause disease, but nucleic acid testing reagents can only detect one type.
Pathogens, so he asked his students to develop a new PCR detection method that can detect various previously unknown coronaviruses.
The first batch of samples tested came from Sarawak, East Malaysia.
Most of the patients were children living in the countryside with a history of frequent contact with poultry, livestock and wild animals.
In the samples of 8 patients, the research team found a previously unseen canine coronavirus (CCoV).
The first reaction of the research team was that the test was wrong, because there has never been a report of canine coronavirus infecting humans before, so Gregory Gray sent the test samples to Ohio State University, but the results of the test again showed that they were correct.
This is indeed the case.
A virus that can infect humans.
Two of the eight samples had a high CCoV content, which was sufficient for further experiments.
One of the samples showed obvious cytopathic effects when infected with dog tumor cells (A72).
But if you want to prove that it can cause disease in humans, you have to inject the virus directly into people.
This obviously cannot pass the ethical barrier.
The research team performed a complete genome sequencing of the CCoV-HuPn-2018 virus and found that it has the highest homology with another known CCoV, namely CCoV TN-449, but the S protein S2 subunit is similar to the cat coronavirus (FCoV).
) The homology of WSU 79-1683 is as high as 97%, which proves that this is a canine-feline recombinant coronavirus. In fact, CCoV-HuPn-2018 has a high degree of homology, and there are other viruses.
Further analysis also shows that CCoV-HuPn-2018 has a specific deletion in the middle part of the N protein (aa-12), which can infect humans, The more dangerous SARS virus (SARS-CoV) and the new coronavirus also have such N protein changes, indicating that CCoV-HuPn-2018 may really be able to be transmitted directly from animals to humans.
Among the seven human-causing coronaviruses previously discovered by humans, four of them only cause general cold symptoms, and then SARS, new coronaviruses and Middle East respiratory syndrome virus (MERS-CoV).
The research team will continue to expand the scope of sample testing in the future to see if there is more evidence that CCoV-HuPn-2018 causes human illness.
Professor Gregory Gray said in a report in "Science" that "the spread of viruses from animals to humans is a long process, not as scary as in movies" [3], so humans still have time to establish pathogens in animals in hotspots.
However, Singularity is really afraid that “human beings cannot learn any lessons from history”.
References: 1.
Vlasova AN, Diaz A, Damtie D, et al.
Novel Canine Coronavirus Isolated from a Hospitalized Pneumonia Patient, East Malaysia[J].
Clinical Infectious Diseases, 2021.
2.
/10.
1101/2021.
01.
26.
428212v1.
full3.
header image source: Pixabay Author of this article | Tan large
