Disruption . . . Hopefully, we can conquer the tumor! Team zhu Yongfa of Tsinghua University developed a new method to eliminate tumors within 10 minutes, and the survival rate of mice increased from 0 to 100% in 50 days

According to the latest statistics, cancer is still a serious threat to public health in the world, and new cancer treatment methods are urgently needed.at present, most clinical cancer therapies are still difficult to completely cure cancer and have serious side effects, which lead to metastasis, proliferation and drug resistance mutations.fast, complete, targeted and safe cancer treatment is still the key issue in cancer treatment.on July 2, 2020, Zhu Yongfa of Tsinghua University and Shanye Guan, Institute of physical and chemical technology, Chinese Academy of Sciences, jointly published the title "photogenerated holes induced rapid killing of solid tubes by the supramolecular porphyrin" online in the National Science Review In this study, a supramolecular photocatalyst nano SA TCPP was established, which can be irradiated at the wavelength of 600-700 nm to treat solid tumors. Solid tumors (100 mm3) can be eliminated within 10 minutes.the 50 day survival rate of mice increased from 0% to 100%.because of size selection, porphyrin based photocatalysts can be targeted and internalized by cancer cells without entering normal cells.the therapy has no toxicity and side effects on normal cells and organisms.moreover, photocatalytic therapy is effective for a variety of cancer cell lines.because of its high efficiency, safety and versatility, photocatalytic therapy provides us with a new way to conquer tumors.according to the latest statistics, cancer is still a serious threat to public health in the world, and new cancer treatment methods are urgently needed.at present, most clinical cancer therapies are still difficult to completely cure cancer and have serious side effects, which lead to metastasis, proliferation and drug resistance mutations.nanodrugs for cancer treatment have been widely used in preclinical and clinical applications, especially phototherapy, which can accurately target tumors and minimize the damage to normal cells.photothermal therapy (PTT) uses the photothermal effect of nanoparticles to generate local heat above 42 ° C to kill cancer cells.PTT has some attractive unique advantages, such as its low invasiveness and high effectiveness.however, metal and carbon based nanomaterials of photothermal agents (PTA) are difficult to metabolize, resulting in cumulative toxicity and permanent damage to the brain, kidney, liver and other organs.because of its small organic molecules, the relatively low photothermal stability and photothermal conversion efficiency (PCE) limit its clinical application.for other PTA, such as other inorganic 2D materials and polymer nanoparticles, the synthesis strategy is too complex and usually has a large size distribution. another clinically approved phototherapy is photodynamic therapy (PDT), which uses light activated photosensitizers (PSS) and exogenous reactive oxygen species (ROS) produced by oxygen to kill cancer cells. because ROS is a chemical reactive free radical or a non free radical molecule derived from oxygen molecules, PDT is an oxygen dependent process that can destroy a variety of cancer cells. as a result, repeated PDT treatment was not resistant. despite these advantages, the hypoxic tumor microenvironment requires oxidative intermediates, so it is usually inefficient and requires repeated treatment. photocatalysis driven by photon energy can oxidize or reduce substrate molecules. recently, photocatalysts have been used in the field of antibacterial and antiviral activities related to life, which has stimulated the potential role of photocatalysts in tumor treatment. not long ago, researchers reported a method for the preparation of supramolecular photocatalysts for self-assembly of tetracarboxyphenyl porphyrin (sa-tcpp), and demonstrated its oxidation ability under the excitation of 420-750 nm wavelength. porphyrin based molecular drugs are widely used in PDT due to their excellent biological capacity and singlet oxygen release, and some of them have achieved clinical application. it is well known that one of the obstacles to phototherapy is its penetration depth, which is also important for detection. the red / NIR light region between 600 and 1200 nm is called the optical window of tissue, which is conducive to deep penetration. in view of the above situation, the researchers tried to use the photogenerated pores of sa-tcpp to achieve strong oxidative killing of solid tumors and form the theragnostic system of cancer cells. if this idea is feasible, then it may be more effective than PDT and PTT because it does not require heat and oxygen, which is more suitable for tumor microenvironment. therapeutic mechanism (picture from National Science Review) this study established a supramolecular photocatalyst nano sa-tcpp, which can irradiate at 600-700 nm wavelength to treat solid tumor. Solid tumor (100 mm3) can be eliminated within 10 minutes. the 50 day survival rate of mice increased from 0% to 100%. because of size selection, porphyrin based photocatalysts can be targeted and internalized by cancer cells without entering normal cells. the therapy has no toxicity and side effects on normal cells and organisms. moreover, photocatalytic therapy is effective for a variety of cancer cell lines. because of its high efficiency, safety and versatility, photocatalytic therapy provides us with a new way to conquer tumors. reference message: