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Disruption of N-glycan expression on tumor cells improves the efficacy of chimeric antigen receptor T cells against solid malignancies

 Last Update: 2022-02-21
 Source: Internet
 Author: User

Deglycosylation

Chimeric antigen receptor (CAR) T cells are less effective for solid tumors than for hematological malignancies

One of the resistance mechanisms that tumor cells use to prevent CAR-T cell killing is through glycosylation of surface proteins

However, for the first time in a human solid tumor study, some unique barriers have been identified that lead to poor efficacy

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