Distance produces beauty! Cell Sub-Journal: Intestinal-produced "sterilizing fluid" is maintaining health

during the New Crown pandemic, disinfectant can be a sought-after goods, households and medical institutions will use every day. But as we all know, it can only be used for in vitro and environmental disinfection, not in the body, because it can be life-threatening.but a new study tells us that our bodies are also producing their own "disinfectants" to maintain intestinal health.a recent study published in Cell Host and Microbe, a team led by the University of California, Davis, found that an enzyme in the colon's inner wall releases hydrogen peroxide to protect gut microbiota. The study rewrites the understanding of how the gut works and sheds light on the way microbes organize spatially in the colon. At the same time, the authors call for a new way to treat intestinal inflammation.hydrogen peroxide (H2O2) is a strong oxidant that can be mixed with water in any proportion. Hydrogen peroxide aqueous solution, commonly known as hydrogen peroxide, is commonly used for medical wound disinfection and environmental disinfection.most microbes live in our large intestine, which is actually a natural low-oxygen environment.more than half of the body's microbes are resistant to oxygen," said andreas Bäumler, a professor of microbiology and immunology at the University of California, Davis School of Medicine and lead author of the study. We found that gut bacteria are far from the surface of the colon, which is essential to avoid inflammation caused by the unintended immune response of good bacteria. Previousthat this spatial separation is maintained by oxygen released by cells to prevent microbes from getting too close to the intestinal wall. But the study overturns previous theories.。 "We looked at the spatial relationship between gut bacteria and their host colon and found that cells in the inner walls of the colon release hydrogen peroxide instead of oxygen to limit the growth of microorganisms," Bäumler said. Theknow that NOX1 is an enzyme present in the inner walls of the intestine and is an important source of hydrogen peroxide in the colon. Naturally occurring hydrogen peroxide acts as a filter to regulate the location of the microbiome in the colon.researchers used Citrobacter rodentium, a pathogen planted on the surface of the colon, to identify microbial characteristics in the space environment. They found that citric acid bacteria can only release hydrogen peroxide when attached directly to the walls of the intestines. This indicates that the body uses hydrogen peroxide to protect the surface of the colon. At the same time, prevent intestinal bacteria from mixing with areas of the body that should not be in contact, thus avoiding inflammation.
。Treat intestinal inflammation with natural "filters when the intestinal bacteriosty is out of order, it can trigger inflammation and lead to symptoms of digestive disorders such as nausea and bloating. Traditional treatments for intestinal inflammation mainly use antibiotics or probiotics to target bacteria.but this new study suggests that a different approach is needed to treat intestinal inflammation and bacteriosurological disorders. The researchers point out that this is an opportunity to restore host function rather than eliminate microorganisms.。 "We need to shift the direction of the treatment of intestinal inflammation from targeting bacteria to restoring the function of 'filters', " says Bäumler. Linkpaper: