Does the gut flora play a role in autoimmune diseases?

There are trillions of microbes living in a healthy intestine. They have co-evolved with us, and their survival depends on us, just as our health also depends on them . For example, we provide nutrients to bacteria, which control our immune system, digest certain carbohydrates that we cannot digest, and make vitamins and other important compounds that we cannot produce . This wonderful symbiotic relationship helps many important functions of our body and maintains our physical and mental health . The intestinal flora can affect us in many ways, from how we store fat to whether we feel happy, anxious or depressed . Intestinal flora has been linked to more and more diseases, such as Crohn's disease, ulcerative colitis, irritable bowel syndrome, obesity, diabetes, and depression . These diseases are not caused by a single bacteria, but by changes in the entire intestinal flora . When the normal intestinal flora is disturbed, whether it is the use of antibiotics, bacterial infections or other factors, it may cause imbalance of the intestinal flora or excessive growth of small intestinal bacteria . Since a large part of our immune system is in the intestine, the imbalance of intestinal flora also plays an important role in the occurrence of autoimmune diseases. Supporting our intestinal flora may help prevent or even treat autoimmune diseases . 　　What is an autoimmune disease? 　　The body's immune system is a powerful shield that protects the body from foreign invaders, toxins, and abnormal processes that can cause disease . The health of the immune system is often regarded as a measure of the overall health of the body . The immune system is the body's security force, it can protect us from all kinds of foreign problematic substances . When the imbalance of the body develops to a certain extent and cancer cells begin to grow, the immune system is also responsible for breaking down the tumor cells and stopping the cancer process . In order to better perform various functions, the immune system is very complex, enabling it to deal with almost any challenge . 　　However, when the same immune response begins to attack one's own cells and tissues, these powerful processes will trigger a series of effects, leading to diseases in the body, and the result is an autoimmune disease . Autoimmune diseases are usually defined as the process by which the body's immune system attacks its own cells and tissues . The current understanding of autoimmunity believes that this self-attack is a mistake made by the immune system . By attacking healthy tissues, the immune system causes a disease process instead of protecting the body from disease . 　　Under normal circumstances, the immune system will only respond to specific pathogens, such as cold viruses. Once the pathogen is cleared, the immune system will return to its normal state . In the case of autoimmune diseases, the immune system tends to remain highly vigilant, leading to chronic inflammation . 　　The human body has more than 150 kinds of autoimmune diseases, and the autoimmune response can affect almost every organ system of the body . It is estimated that about 5-8% of the global population is threatened by autoimmune diseases, and this number is increasing year by year . 　　So, what causes the immune system to attack normal and healthy human cells? 　　The culprit of autoimmune diseases For 　　a person to suffer from autoimmune diseases, it is generally believed that there must be three different factors: genetic susceptibility, environmental triggers and intestinal leakage . These three factors have proved to be necessary conditions for the occurrence of most autoimmune diseases . 　　Genetic susceptibility: Certain genes make individuals more susceptible to certain diseases . If a person has a family history of autoimmune diseases, then your risk of developing autoimmune diseases is also higher . 　　Environmental incentives: The second factor in the occurrence of autoimmune diseases is environmental incentives . It does not mean that a person who has a susceptibility gene will have autoimmune diseases. It also depends on his lifestyle, including dietary choices, exposure to toxins and stress . Due to different lifestyles, one person's genes may be expressed, while another may not . Environment and lifestyle will affect the expression of genes. It is the environment around the genes that determines our health or disease status, not the genes themselves . Our bodies may be exposed to environmental triggers all kinds of unhealthy, including harmful food, harmful bacteria, viruses, cosmetic products, pesticides, preservatives or food additives, and so on . When environmental toxins accumulate to a certain level, exceeding the threshold that we can bear, it may lead to the occurrence of diseases . 　　Intestinal leakage: The so-called intestinal leakage is the increase in intestinal permeability, that is, the tight junctions between intestinal cells are destroyed, which makes some macromolecular substances that cannot pass through (such as incompletely digested food or bacteria, etc. ) pass through. It enters our bloodstream through the intestinal wall, triggering an immune response, leading to systemic inflammation . There are many causes of intestinal leakage, such as food allergies, harmful food intake, intestinal infections or chronic stress . 　　Does the intestinal flora play a role in autoimmune diseases? 　　Now, people are paying more and more attention to the importance of intestinal flora in health and disease. Even a slight imbalance can have far-reaching consequences . Obviously, the intestinal flora profoundly affects our immune system, and more and more studies have also provided insights on how changes in the intestinal flora can be a trigger for the occurrence of autoimmune diseases, indicating that the intestinal flora Your health may be a key factor in whether we will develop autoimmune diseases . 　　In terms of global morbidity and mortality, type 1 diabetes and rheumatoid arthritis are the two most common autoimmune diseases . Let's take these two diseases as examples to see how the intestinal flora plays a role in autoimmune diseases . 　　Type 1 diabetes 　　Type 1 diabetes is an autoimmune disease in which autoantibodies destroy insulin-producing beta cells in the pancreas, resulting in insulin deficiency and abnormal blood sugar . Most patients are diagnosed in childhood or adolescence . Type 1 diabetes has a certain genetic correlation. However, in the study of twins, only about 50% of twins will suffer from this disease at the same time, which shows that the occurrence of the disease does not only depend on genes . 　　Research on the differences in intestinal flora between patients with type 1 diabetes and healthy people found the following differences: 　　Children with type 1 diabetes have fewer beneficial bacteria in their bodies . 　　The stability and diversity of intestinal bacteria in children with type 1 diabetes is low . 　　There are significant differences in intestinal flora composition and metabolic capacity between people with type 1 diabetes and those without type 1 diabetes . 　　After type 1 diabetes patients received treatment to normalize their blood sugar levels, the microbial diversity of these individuals also restored . 　　In general, type 1 diabetes is associated with the destruction of normal intestinal flora . At this time, the disease is not caused by a single pathogen. In genetically susceptible individuals, the destruction of the normal intestinal flora provides an environment in which the disease may occur . 　　Rheumatoid 　　arthritis Rheumatoid arthritis affects up to 1% of adults worldwide. It is an autoimmune disease that affects many joints throughout the body, most commonly the hands, feet, wrists and ankles. Joints . 　　Like type 1 diabetes, rheumatoid arthritis has certain genetic associations . However, the study of twins once again proved that compared with type 1 diabetes, genetics plays a smaller role in the development of rheumatoid arthritis . The study once again confirmed the relationship between the intestinal flora and the occurrence and progression of rheumatoid arthritis . 　　Prevotella copri, a bacterium of the genus Prevotella called Prevotella copri, in the human intestines is more numerous in newly diagnosed patients with rheumatoid arthritis than healthy people or patients with rheumatoid arthritis undergoing treatment. 　　Lack of known rheumatoid arthritis susceptibility In patients with genes, the relative abundance of Prevotella copri is higher than those with these susceptibility genes, which means that in individuals with genetic susceptibility, less Prevotella copri may be enough to cause disease . 　　Oral flora and health are also related to rheumatoid arthritis: 　　Compared with healthy people, newly diagnosed rheumatoid arthritis patients have more severe periodontitis and more tooth loss, despite oral hygiene Normal . 　　The severity of periodontal disease can be related to the severity of rheumatoid arthritis disease activity . 　　In animal models, specific bacteria living in the mouth can increase the severity of joint disease . 　　Some specific bacteria exist in both the dental plaque and the joint fluid of patients with rheumatoid arthritis . 　　The relationship between many other autoimmune diseases and the intestinal flora is gradually being explored, and more and more evidence also shows that the destruction of the intestinal flora is related to the occurrence of many other types of autoimmune diseases, including celiac disease. , systemic lupus erythematosus, autoimmune encephalomyelitis, Hashimoto's thyroiditis and the like . 　　Most of these studies only confirm that there is a clear correlation between changes in the intestinal flora and autoimmune diseases. We are not yet fully aware of whether the imbalance of the intestinal flora leads to the occurrence of autoimmune diseases or the excess of the immune system. Active and wrong attacks lead to imbalance of the intestinal flora . However, some interventions aimed at regulating the intestinal flora seem to improve the symptoms of certain autoimmune diseases, which seems to indicate the role of intestinal flora in the occurrence of autoimmune diseases . 　　Summarize 　　The intestinal flora is very important for the development of the immune system. 70-80% of our entire immune system resides in the intestine . The intestine is a training camp for the immune system. The intestinal bacteria and the immune system work together to help us form a healthy immune response. However, once the balance is out of balance, it may cause diseases. For example, the immune system mistakenly attacks our own cells, which is ourselves. Immune disease . 　　When the intestinal flora is unbalanced, harmful bacteria grow excessively, which may lead to increased intestinal permeability and systemic inflammation, thereby increasing the risk of autoimmune diseases . Many factors that affect the intestinal flora are also environmental factors that increase the risk of autoimmune diseases . Among them, diet is one of the biggest environmental factors leading to the occurrence of autoimmune diseases, and controlling diet is one of the keys to maintaining a healthy intestinal flora and treating autoimmune diseases .   Disclaimer: This article only represents the author's personal views and has nothing to do with China Probiotics. com . The originality and the text and content stated in the article have not been verified by this site. This site does not make any guarantee or commitment to the authenticity, completeness, and timeliness of this article, all or part of the content, and the text. 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There are trillions of microbes living in a healthy intestine.
They have co-evolved with us, and their survival depends on us, just as our health also depends on them
.
For example, we provide nutrients to bacteria, which control our immune system, digest certain carbohydrates that we cannot digest, and make vitamins and other important compounds that we cannot produce
.
This wonderful symbiotic relationship helps many important functions of our body and maintains our physical and mental health
.


　　The intestinal flora can affect us in many ways, from how we store fat to whether we feel happy, anxious or depressed
.
Intestinal flora has been linked to more and more diseases, such as Crohn's disease, ulcerative colitis, irritable bowel syndrome, obesity, diabetes, and depression
.
These diseases are not caused by a single bacteria, but by changes in the entire intestinal flora
.


　　When the normal intestinal flora is disturbed, whether it is the use of antibiotics, bacterial infections or other factors, it may cause imbalance of the intestinal flora or excessive growth of small intestinal bacteria
.
Since a large part of our immune system is in the intestine, the imbalance of intestinal flora also plays an important role in the occurrence of autoimmune diseases.
Supporting our intestinal flora may help prevent or even treat autoimmune diseases
.


　　What is an autoimmune disease?

　　The body's immune system is a powerful shield that protects the body from foreign invaders, toxins, and abnormal processes that can cause disease
.
The health of the immune system is often regarded as a measure of the overall health of the body
.
The immune system is the body's security force, it can protect us from all kinds of foreign problematic substances
.
When the imbalance of the body develops to a certain extent and cancer cells begin to grow, the immune system is also responsible for breaking down the tumor cells and stopping the cancer process
.
In order to better perform various functions, the immune system is very complex, enabling it to deal with almost any challenge
.


　　However, when the same immune response begins to attack one's own cells and tissues, these powerful processes will trigger a series of effects, leading to diseases in the body, and the result is an autoimmune disease
.
Autoimmune diseases are usually defined as the process by which the body's immune system attacks its own cells and tissues
.
The current understanding of autoimmunity believes that this self-attack is a mistake made by the immune system
.
By attacking healthy tissues, the immune system causes a disease process instead of protecting the body from disease
.


　　Under normal circumstances, the immune system will only respond to specific pathogens, such as cold viruses.
Once the pathogen is cleared, the immune system will return to its normal state
.
In the case of autoimmune diseases, the immune system tends to remain highly vigilant, leading to chronic inflammation
.


　　The human body has more than 150 kinds of autoimmune diseases, and the autoimmune response can affect almost every organ system of the body
.
It is estimated that about 5-8% of the global population is threatened by autoimmune diseases, and this number is increasing year by year
.


　　So, what causes the immune system to attack normal and healthy human cells?

　　The culprit of autoimmune diseases
For

　　a person to suffer from autoimmune diseases, it is generally believed that there must be three different factors: genetic susceptibility, environmental triggers and intestinal leakage
.
These three factors have proved to be necessary conditions for the occurrence of most autoimmune diseases
.


　　Genetic susceptibility: Certain genes make individuals more susceptible to certain diseases
.
If a person has a family history of autoimmune diseases, then your risk of developing autoimmune diseases is also higher
.


　　Environmental incentives: The second factor in the occurrence of autoimmune diseases is environmental incentives
.
It does not mean that a person who has a susceptibility gene will have autoimmune diseases.
It also depends on his lifestyle, including dietary choices, exposure to toxins and stress
.
Due to different lifestyles, one person's genes may be expressed, while another may not
.
Environment and lifestyle will affect the expression of genes.
It is the environment around the genes that determines our health or disease status, not the genes themselves
.
Our bodies may be exposed to environmental triggers all kinds of unhealthy, including harmful food, harmful bacteria, viruses, cosmetic products, pesticides, preservatives or food additives, and so on
.
When environmental toxins accumulate to a certain level, exceeding the threshold that we can bear, it may lead to the occurrence of diseases
.


　　Intestinal leakage: The so-called intestinal leakage is the increase in intestinal permeability, that is, the tight junctions between intestinal cells are destroyed, which makes some macromolecular substances that cannot pass through (such as incompletely digested food or bacteria, etc.
) pass through.
It enters our bloodstream through the intestinal wall, triggering an immune response, leading to systemic inflammation
.
There are many causes of intestinal leakage, such as food allergies, harmful food intake, intestinal infections or chronic stress
.


　　Does the intestinal flora play a role in autoimmune diseases?

　　Now, people are paying more and more attention to the importance of intestinal flora in health and disease.
Even a slight imbalance can have far-reaching consequences
.
Obviously, the intestinal flora profoundly affects our immune system, and more and more studies have also provided insights on how changes in the intestinal flora can be a trigger for the occurrence of autoimmune diseases, indicating that the intestinal flora Your health may be a key factor in whether we will develop autoimmune diseases
.


　　In terms of global morbidity and mortality, type 1 diabetes and rheumatoid arthritis are the two most common autoimmune diseases
.
Let's take these two diseases as examples to see how the intestinal flora plays a role in autoimmune diseases
.


　　Type 1 diabetes

　　Type 1 diabetes is an autoimmune disease in which autoantibodies destroy insulin-producing beta cells in the pancreas, resulting in insulin deficiency and abnormal blood sugar
.
Most patients are diagnosed in childhood or adolescence
.
Type 1 diabetes has a certain genetic correlation.
However, in the study of twins, only about 50% of twins will suffer from this disease at the same time, which shows that the occurrence of the disease does not only depend on genes
.


　　Research on the differences in intestinal flora between patients with type 1 diabetes and healthy people found the following differences:

　　Children with type 1 diabetes have fewer beneficial bacteria in their bodies
.


　　The stability and diversity of intestinal bacteria in children with type 1 diabetes is low
.


　　There are significant differences in intestinal flora composition and metabolic capacity between people with type 1 diabetes and those without type 1 diabetes
.


　　After type 1 diabetes patients received treatment to normalize their blood sugar levels, the microbial diversity of these individuals also restored
.


　　In general, type 1 diabetes is associated with the destruction of normal intestinal flora
.
At this time, the disease is not caused by a single pathogen.
In genetically susceptible individuals, the destruction of the normal intestinal flora provides an environment in which the disease may occur
.


　　Rheumatoid

　　arthritis Rheumatoid arthritis affects up to 1% of adults worldwide.
It is an autoimmune disease that affects many joints throughout the body, most commonly the hands, feet, wrists and ankles.
Joints
.


　　Like type 1 diabetes, rheumatoid arthritis has certain genetic associations
.
However, the study of twins once again proved that compared with type 1 diabetes, genetics plays a smaller role in the development of rheumatoid arthritis
.
The study once again confirmed the relationship between the intestinal flora and the occurrence and progression of rheumatoid arthritis
.


　　Prevotella copri, a bacterium of the genus Prevotella called Prevotella copri, in the human intestines is more numerous in newly diagnosed patients with rheumatoid arthritis than healthy people or patients with rheumatoid arthritis undergoing treatment.


　　Lack of known rheumatoid arthritis susceptibility In patients with genes, the relative abundance of Prevotella copri is higher than those with these susceptibility genes, which means that in individuals with genetic susceptibility, less Prevotella copri may be enough to cause disease
.


　　Oral flora and health are also related to rheumatoid arthritis:

　　Compared with healthy people, newly diagnosed rheumatoid arthritis patients have more severe periodontitis and more tooth loss, despite oral hygiene Normal
.


　　The severity of periodontal disease can be related to the severity of rheumatoid arthritis disease activity
.


　　In animal models, specific bacteria living in the mouth can increase the severity of joint disease
.


　　Some specific bacteria exist in both the dental plaque and the joint fluid of patients with rheumatoid arthritis
.


　　The relationship between many other autoimmune diseases and the intestinal flora is gradually being explored, and more and more evidence also shows that the destruction of the intestinal flora is related to the occurrence of many other types of autoimmune diseases, including celiac disease.
, systemic lupus erythematosus, autoimmune encephalomyelitis, Hashimoto's thyroiditis and the like
.


　　Most of these studies only confirm that there is a clear correlation between changes in the intestinal flora and autoimmune diseases.
We are not yet fully aware of whether the imbalance of the intestinal flora leads to the occurrence of autoimmune diseases or the excess of the immune system.
Active and wrong attacks lead to imbalance of the intestinal flora
.
However, some interventions aimed at regulating the intestinal flora seem to improve the symptoms of certain autoimmune diseases, which seems to indicate the role of intestinal flora in the occurrence of autoimmune diseases
.


　　Summarize

　　The intestinal flora is very important for the development of the immune system.
70-80% of our entire immune system resides in the intestine
.
The intestine is a training camp for the immune system.
The intestinal bacteria and the immune system work together to help us form a healthy immune response.
However, once the balance is out of balance, it may cause diseases.
For example, the immune system mistakenly attacks our own cells, which is ourselves.
Immune disease
.


　　When the intestinal flora is unbalanced, harmful bacteria grow excessively, which may lead to increased intestinal permeability and systemic inflammation, thereby increasing the risk of autoimmune diseases
.
Many factors that affect the intestinal flora are also environmental factors that increase the risk of autoimmune diseases
.
Among them, diet is one of the biggest environmental factors leading to the occurrence of autoimmune diseases, and controlling diet is one of the keys to maintaining a healthy intestinal flora and treating autoimmune diseases
.

---

There are trillions of microbes living in a healthy intestine.
They have co-evolved with us, and their survival depends on us, just as our health also depends on them
.
For example, we provide nutrients to bacteria, which control our immune system, digest certain carbohydrates that we cannot digest, and make vitamins and other important compounds that we cannot produce
.
This wonderful symbiotic relationship helps many important functions of our body and maintains our physical and mental health
.


　　The intestinal flora can affect us in many ways, from how we store fat to whether we feel happy, anxious or depressed
.
Intestinal flora has been linked to more and more diseases, such as Crohn's disease, ulcerative colitis, irritable bowel syndrome, obesity, diabetes, and depression
.
These diseases are not caused by a single bacteria, but by changes in the entire intestinal flora
.


　　When the normal intestinal flora is disturbed, whether it is the use of antibiotics, bacterial infections or other factors, it may cause imbalance of the intestinal flora or excessive growth of small intestinal bacteria
.
Since a large part of our immune system is in the intestine, the imbalance of intestinal flora also plays an important role in the occurrence of autoimmune diseases.
Supporting our intestinal flora may help prevent or even treat autoimmune diseases
.


　　What is an autoimmune disease?

　　The body's immune system is a powerful shield that protects the body from foreign invaders, toxins, and abnormal processes that can cause disease
.
The health of the immune system is often regarded as a measure of the overall health of the body
.
The immune system is the body's security force, it can protect us from all kinds of foreign problematic substances
.
When the imbalance of the body develops to a certain extent and cancer cells begin to grow, the immune system is also responsible for breaking down the tumor cells and stopping the cancer process
.
In order to better perform various functions, the immune system is very complex, enabling it to deal with almost any challenge
.


　　However, when the same immune response begins to attack one's own cells and tissues, these powerful processes will trigger a series of effects, leading to diseases in the body, and the result is an autoimmune disease
.
Autoimmune diseases are usually defined as the process by which the body's immune system attacks its own cells and tissues
.
The current understanding of autoimmunity believes that this self-attack is a mistake made by the immune system
.
By attacking healthy tissues, the immune system causes a disease process instead of protecting the body from disease
.


　　Under normal circumstances, the immune system will only respond to specific pathogens, such as cold viruses.
Once the pathogen is cleared, the immune system will return to its normal state
.
In the case of autoimmune diseases, the immune system tends to remain highly vigilant, leading to chronic inflammation
.


　　The human body has more than 150 kinds of autoimmune diseases, and the autoimmune response can affect almost every organ system of the body
.
It is estimated that about 5-8% of the global population is threatened by autoimmune diseases, and this number is increasing year by year
.


　　So, what causes the immune system to attack normal and healthy human cells?

　　The culprit of autoimmune diseases
For

　　a person to suffer from autoimmune diseases, it is generally believed that there must be three different factors: genetic susceptibility, environmental triggers and intestinal leakage
.
These three factors have proved to be necessary conditions for the occurrence of most autoimmune diseases
.


　　Genetic susceptibility: Certain genes make individuals more susceptible to certain diseases
.
If a person has a family history of autoimmune diseases, then your risk of developing autoimmune diseases is also higher
.


　　Environmental incentives: The second factor in the occurrence of autoimmune diseases is environmental incentives
.
It does not mean that a person who has a susceptibility gene will have autoimmune diseases.
It also depends on his lifestyle, including dietary choices, exposure to toxins and stress
.
Due to different lifestyles, one person's genes may be expressed, while another may not
.
Environment and lifestyle will affect the expression of genes.
It is the environment around the genes that determines our health or disease status, not the genes themselves
.
Our bodies may be exposed to environmental triggers all kinds of unhealthy, including harmful food, harmful bacteria, viruses, cosmetic products, pesticides, preservatives or food additives, and so on
.
When environmental toxins accumulate to a certain level, exceeding the threshold that we can bear, it may lead to the occurrence of diseases
.


　　Intestinal leakage: The so-called intestinal leakage is the increase in intestinal permeability, that is, the tight junctions between intestinal cells are destroyed, which makes some macromolecular substances that cannot pass through (such as incompletely digested food or bacteria, etc.
) pass through.
It enters our bloodstream through the intestinal wall, triggering an immune response, leading to systemic inflammation
.
There are many causes of intestinal leakage, such as food allergies, harmful food intake, intestinal infections or chronic stress
.


　　Does the intestinal flora play a role in autoimmune diseases?

　　Now, people are paying more and more attention to the importance of intestinal flora in health and disease.
Even a slight imbalance can have far-reaching consequences
.
Obviously, the intestinal flora profoundly affects our immune system, and more and more studies have also provided insights on how changes in the intestinal flora can be a trigger for the occurrence of autoimmune diseases, indicating that the intestinal flora Your health may be a key factor in whether we will develop autoimmune diseases
.


　　In terms of global morbidity and mortality, type 1 diabetes and rheumatoid arthritis are the two most common autoimmune diseases
.
Let's take these two diseases as examples to see how the intestinal flora plays a role in autoimmune diseases
.


　　Type 1 diabetes

　　Type 1 diabetes is an autoimmune disease in which autoantibodies destroy insulin-producing beta cells in the pancreas, resulting in insulin deficiency and abnormal blood sugar
.
Most patients are diagnosed in childhood or adolescence
.
Type 1 diabetes has a certain genetic correlation.
However, in the study of twins, only about 50% of twins will suffer from this disease at the same time, which shows that the occurrence of the disease does not only depend on genes
.


　　Research on the differences in intestinal flora between patients with type 1 diabetes and healthy people found the following differences:

　　Children with type 1 diabetes have fewer beneficial bacteria in their bodies
.


　　The stability and diversity of intestinal bacteria in children with type 1 diabetes is low
.


　　There are significant differences in intestinal flora composition and metabolic capacity between people with type 1 diabetes and those without type 1 diabetes
.


　　After type 1 diabetes patients received treatment to normalize their blood sugar levels, the microbial diversity of these individuals also restored
.


　　In general, type 1 diabetes is associated with the destruction of normal intestinal flora
.
At this time, the disease is not caused by a single pathogen.
In genetically susceptible individuals, the destruction of the normal intestinal flora provides an environment in which the disease may occur
.


　　Rheumatoid

　　arthritis Rheumatoid arthritis affects up to 1% of adults worldwide.
It is an autoimmune disease that affects many joints throughout the body, most commonly the hands, feet, wrists and ankles.
Joints
.


　　Like type 1 diabetes, rheumatoid arthritis has certain genetic associations
.
However, the study of twins once again proved that compared with type 1 diabetes, genetics plays a smaller role in the development of rheumatoid arthritis
.
The study once again confirmed the relationship between the intestinal flora and the occurrence and progression of rheumatoid arthritis
.


　　Prevotella copri, a bacterium of the genus Prevotella called Prevotella copri, in the human intestines is more numerous in newly diagnosed patients with rheumatoid arthritis than healthy people or patients with rheumatoid arthritis undergoing treatment.


　　Lack of known rheumatoid arthritis susceptibility In patients with genes, the relative abundance of Prevotella copri is higher than those with these susceptibility genes, which means that in individuals with genetic susceptibility, less Prevotella copri may be enough to cause disease
.


　　Oral flora and health are also related to rheumatoid arthritis:

　　Compared with healthy people, newly diagnosed rheumatoid arthritis patients have more severe periodontitis and more tooth loss, despite oral hygiene Normal
.


　　The severity of periodontal disease can be related to the severity of rheumatoid arthritis disease activity
.


　　In animal models, specific bacteria living in the mouth can increase the severity of joint disease
.


　　Some specific bacteria exist in both the dental plaque and the joint fluid of patients with rheumatoid arthritis
.


　　The relationship between many other autoimmune diseases and the intestinal flora is gradually being explored, and more and more evidence also shows that the destruction of the intestinal flora is related to the occurrence of many other types of autoimmune diseases, including celiac disease.
, systemic lupus erythematosus, autoimmune encephalomyelitis, Hashimoto's thyroiditis and the like
.


　　Most of these studies only confirm that there is a clear correlation between changes in the intestinal flora and autoimmune diseases.
We are not yet fully aware of whether the imbalance of the intestinal flora leads to the occurrence of autoimmune diseases or the excess of the immune system.
Active and wrong attacks lead to imbalance of the intestinal flora
.
However, some interventions aimed at regulating the intestinal flora seem to improve the symptoms of certain autoimmune diseases, which seems to indicate the role of intestinal flora in the occurrence of autoimmune diseases
.


　　Summarize

　　The intestinal flora is very important for the development of the immune system.
70-80% of our entire immune system resides in the intestine
.
The intestine is a training camp for the immune system.
The intestinal bacteria and the immune system work together to help us form a healthy immune response.
However, once the balance is out of balance, it may cause diseases.
For example, the immune system mistakenly attacks our own cells, which is ourselves.
Immune disease
.


　　When the intestinal flora is unbalanced, harmful bacteria grow excessively, which may lead to increased intestinal permeability and systemic inflammation, thereby increasing the risk of autoimmune diseases
.
Many factors that affect the intestinal flora are also environmental factors that increase the risk of autoimmune diseases
.
Among them, diet is one of the biggest environmental factors leading to the occurrence of autoimmune diseases, and controlling diet is one of the keys to maintaining a healthy intestinal flora and treating autoimmune diseases
.

---

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