Dying cells can protect neighboring cells to maintain tissue integrity, and purple is epithelial pores caused by uncoordinated cell death
In order to renew the tissues, the human body must constantly remove millions of dead cells without compromising the integrity, form and connectivity of the tissues
The researchers said that this protection mechanism is very important, if it is broken, it may cause a temporary loss of connectivity
The Romain Levayer Laboratory of the Pasteur Institute and collaborators from institutions such as the National Center for Scientific Research used fruit flies to determine the mechanisms involved in epithelial integrity and the conditions that affect epithelial connectivity
Studies have also shown that inhibiting this protective mechanism has a huge impact on epithelial tissue: cell clearance becomes random, and cells adjacent to dead cells can be cleared at the same time, resulting in repeated loss of connectivity
The first author of the paper, Léo Valon from Levayer's laboratory, said that epithelial tissue is highly sensitive to the spatial distribution of cleared cells
"These observations are very important because they demonstrate the incredible self-organization ability of biological tissues, which enables them to withstand stressful conditions
Related paper information: https://doi.
https://doi.
org/10.
1016/j.
devcel.
2021.
05.
006
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