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Eating too much peanuts will speed up the spread of cancer cells |
Research finds that frequent consumption of peanuts by cancer patients may increase the risk of cancer spreading |
Recently, researchers at the University of Liverpool found that frequent consumption of peanuts by cancer patients may increase the risk of cancer spreading, which is related to the results of previous studies
.
Related research results were published in "Carcinogenesis"
Studies have found that after eating peanuts, peanut agglutinin (PNA, a carbohydrate-binding protein) quickly enters the blood circulation, interacts with blood vessel wall (endothelial) cells, and produces cytokines
.
The cytokines discussed here are IL-6 and MCP-1, which are also well-known cancer metastasis-promoting factors
.
The increase in cytokines causes other endothelial cells to express more cell surface adhesion molecules, making them more attractive to circulating tumor cells, which may promote metastasis
In an earlier study, Yu Lugang, a professor at the University of Liverpool and the corresponding author of the study, and his colleagues reported that PNA entering the blood circulation will bind to a special sugar chain.
This process mainly occurs in precancerous cells and cancer cells.
And interact with a larger protein expressed on the surface of tumor cells in the blood
.
This interaction triggers changes in larger proteins, causing potential adhesion molecules on the surface of cancer cells to be exposed, making cancer cells more sticky and easier to attach to blood vessels
.
It also allows cancer cells to form small clumps, prolonging the survival time of cancer cells in circulation in the body
Yu Lugang said: “Although further studies and investigations are needed, these studies show that frequent consumption of peanuts by cancer patients may increase the risk of metastasis and spread
.
”
However, it is gratifying that a large study in the United States reported that the consumption of peanuts has no significant effect on cancer mortality
.
In another study, the intake of peanuts had no significant effect on the prognosis of prostate cancer patients
"However, the risk of circulating PNA still exists.
At least the relatively high levels of PNA found shortly after the intake of large doses of peanuts may have a significant biological impact on circulating tumor cells at that time and may increase the risk of metastasis
.
Therefore.
The researchers said that the possible impact of large amounts of peanuts consumed by cancer patients on survival needs to be investigated in further population-based epidemiological studies
.
(Source: Xin Yu, China Science News)
Related paper information: https://doi.
https://doi.
org/10.
1093/carcin/bgab059