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    Home > Active Ingredient News > Antitumor Therapy > ESMO Open: Real clinical data on cardiovascular adverse events related to immune checkpoint inhibitors

    ESMO Open: Real clinical data on cardiovascular adverse events related to immune checkpoint inhibitors

    • Last Update: 2021-09-11
    • Source: Internet
    • Author: User
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    Immune checkpoint inhibitors (ICI) may cause life-threatening heart vascular adverse events (CVAE) , which may affect the clinical application of ICI


    Immune checkpoint inhibitors (ICI) may cause life-threatening heart vascular adverse events (CVAE) immunity heart blood vessels

    Jain et al assessed the incidence and clinical determinants of CVAE using ICI treatment in the actual population, findings recently published in the international journal "ESMO Open" on


    "ESMO Open"

    Of the 2,687,301 cancer patients diagnosed between 2011 and 2018, 16,574 received ICI anticancer treatment


    diagnosis

    Cumulative incidence of various adverse cardiovascular events in the two treatment cohorts

    Cumulative incidence of various adverse cardiovascular events in the two treatment cohorts

    The median ages of patients in the ICI group and non-ICI group were 61 years and 65 years, respectively (p<0.


    The highest incidence of CVAE in the ICI group was stroke (4.


    Anti-cytotoxic T lymphocyte-associated protein 4 can increase the risk of heart failure and stroke.


    Original source:

    Original source:

    Jain P,Gutierrez Bugarin J,Guha A et al.


    Cardiovascular adverse events are associated with usage of immune checkpoint inhibitors in real-world clinical data across the United States

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