Eur Heart J: Be careful!

capitalgazette

capitalgazette

Broken heart syndrome (Takotsubo syndrome, TTS) is an acute and usually reversible heart failure syndrome, usually caused by acute emotional or physical stress.

Heartbreak syndrome (Takotsubo syndrome, TTS) Heartbreak syndrome (Takotsubo syndrome, TTS)

TTS tends to occur in postmenopausal women, and the ratio of male to female incidence is 1:9.

Although the potential connection between the brain and the heart has long been considered a key factor in the development of TTS, its underlying mechanism needs further clarification.

In the study published in the European Heart Journal, the research team analyzed brain imaging scans of 104 patients (41 patients who later developed TTS and 63 patients who did not develop TTS).

medsci.

(1) Increased output of sympathetic nervous system and inflammation; (2) Risk of cardiovascular disease.

The study retrospectively identified individuals who underwent clinical 18 F-FDG-PET/CT imaging (N = 104, median age 67.

Among the subgroups with TTS, those with the highest AmygA (>mean+1 SD) developed TTS 2 years earlier than those with lower AmygA after angiography (P=0.

¹⁸ The relationship between stress-related neurobiological activities and TTS risk on F-FDG-PET/CT images.

In a retrospective population with a high malignancy rate, higher AmygA was associated with an increased risk of TTS.

Speculate the neurobiological pathway between stress and Takotsubo syndrome.

immunity

"We have shown that TTS is not only due to rare and sad events, such as the death of a spouse or child in the classic example.

In addition, scientists have also determined the relationship between stress-related brain activity and the individual's bone marrow activity.

When Tawakol hopes to apply the results to the clinic, he hopes that interventions to reduce stress-related brain activity will make it more difficult to develop TTS.

Original link:

Azar Radfar, Shady Abohashem.

oup.
com/eurheartj/advance-article/doi/10.
1093/eurheartj/ehab029/6184791" target="_blank" rel="noopener">Stress-Associated neurobiological Activity Associates with The Risk for and Timing of Subsequent Takotsubo syndrome ,oup.
com/eurheartj/advance-article/doi/10.
1093/eurheartj/ehab029/6184791" target="_blank" rel="noopener"> Stress-Associated neurobiological Activity Associates with The Risk for and Timing of Subsequent Takotsubo syndromeoup.
com/eurheartj/advance-article/doi/10.
1093/eurheartj/ehab029/6184791" target="_blank" rel="noopener"> Stress-Associated neurobiological Activity Associates with The Risk for and Timing of Subsequent Takotsubo syndromein This message