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The incidence of central nervous system malignant tumors is getting higher and higher, and the 5-year relative survival rate is only 35.
diagnosis
DNA copy number variation (CNV) is a quantitative structural rearrangement, including duplication, deletion, and high-order amplification.
The CN2 subtype is associated with the shortest overall survival (OS).
Recently, a study published in the journal European Radiology used MR-based preoperative nomograms to predict the DNA copy number subtypes of LGG patients (CN1-CN3), demonstrating the MR characteristics of low-grade gliomas and the DNA copy number Type of relationship.
The overall survival (OS) data of the patients were analyzed.
The CN2 subtype was associated with the shortest median OS (CN2 subtype vs.
3
Figure 1 Correlation matrix between MR qualitative characteristics and DNA copy number subtypes
Figure 2 (a) No bleeding, unclear edges, no extranodular growth, and volume ≥60 cm 3 are related to CN1 subtypes.
3
Patients with CN2 subtype have the shortest OS.
Patients with CN2 subtype have the shortest OS.
Original source:
Siwei Zhang,Shanshan Wu,Yun Wan,et al.
Siwei Zhang,Shanshan Wu,Yun Wan,et al.
Development of MR-based preoperative nomograms predicting DNA copy number subtype in lower grade gliomas with prognostic implication.
DOI: org/10.
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1007/s00330-020-07350 -2 Leave a message here
