Europe may define titanium dioxide as a carcinogen, paint faces impact

In one group of "inhalation exposure experiments", the incidence of "lung tumors" (benign and malignant) in female rats increased; in the other group of "high-dose inhalation exposure experiments", male rats and female rats suffered from The incidence of "benign lung tumors" has increased
.
In this group of "high-dose inhalation exposure experiments," female rats were diagnosed as "cystic keratinized lesions" due to "squamous cell carcinoma", but were later re-diagnosed as "non-pulmonary tumor keratinized cysts
.
" Both groups of rats and female mice "inhalation exposure experiments" proved negative results
.

The group of experiments that gave rats "intratracheal medication" after using two kinds of titanium dioxide showed that the incidence of benign lung tumors and malignant lung tumors in female rats increased at the same time, while the incidence of lung tumors in hamsters and female mice did not.
Rise
.

The experiments of "gavage", "subcutaneous injection" and "intraperitoneal injection" to rats and mice did not find any significant increase in the incidence of tumors
.

Although humans may be exposed to titanium dioxide through inhalation, ingestion or skin contact, the "interstitial dynamics" of the human lungs after inhalation of titanium dioxide is different from that of laboratory animals
.
(Generally speaking, "particulate characteristics" and "host factors" will affect the deposition pattern of titanium dioxide after inhalation; particles that are insoluble in water, such as monographs related to titanium dioxide are classified as carbon black)
.
The research data of human inhalation of titanium dioxide mainly comes from case reports
.
These data show that titanium dioxide is mainly deposited in "alveolar tissue" and "lymphatic tissue"
.

A clinical investigation study of oral titanium dioxide showed that not only the gastrointestinal tract will selectively absorb titanium dioxide according to the size of the titanium dioxide particles, but the content of titanium dioxide in the blood is also related to the particle size
.
Investigations and studies also show that the "ultra-fine titanium dioxide" used in "sunscreen cream" is safe for human skin.
Titanium dioxide can only penetrate into the outermost cell of the skin, the "stratum corneum
.
" Therefore, healthy skin can effectively prevent the penetration of titanium dioxide into the body
.
There is no research data to prove whether damaged skin can also effectively prevent the penetration of titanium dioxide
.

Indeed, several groups of research investigations have shown that workers exposed to titanium dioxide dust directly inhale titanium dioxide and cause a series of physical diseases, including "pulmonary failure", "pleural plaques and thickening of the pleura", and mild " Alveolar tissue fibrosis" and so on
.
Of course, in these investigations, the workers also came into direct contact with "asbestos" and "silica" at the same time
.

Titanium dioxide can cause varying degrees of "inflammation" and lung-related diseases, including "pulmonary epithelial cell damage", "cholesterol granuloma" and "fibrosis"
.
In animal experiments, when rodents are exposed to "ultra-fine titanium dioxide", the probability of lung lesions is greater than in the environment of "ultra-fine titanium dioxide"
.
The reason for this difference is that the surface area of ​​the particles exerts different pressure on the lungs of animals, and it is also considered to be the result of damage to the medium that isolates and swallows "ultrafine titanium dioxide"
.

Compared with other particles, "Fine titanium dioxide particles" show extremely low toxicity
.
At high concentrations, "Ultrafine titanium dioxide particles" particles can block the phagocytosis of "alveolar macrophages"; however, this phenomenon will not occur if it is replaced with "ultrafine titanium dioxide"
.

Experiments with "ultra-fine titanium dioxide" and "ultra-fine titanium dioxide" and "purified DNA" in a test tube showed that the DNA was damaged, proving that these two substances have extremely strong "oxidizing properties
.
" "Ultra-fine titanium dioxide" exhibits a stronger reaction than "ultra-fine titanium dioxide", especially in environments exposed to sunlight or ultraviolet rays
.

The experiment of "intraperitoneal injection" in mice and rats showed that the mice's "micronucleus of bone marrow cells" and "peripheral blood lymphocytes" increased; in rats, the "lung gland epithelial cells" had "gene mutations"
.
In the experiment of "intratracheal medication" in rats, no oxidation of DNA was found in the lung tissue of the rats
.

China's titanium dioxide industry technology innovation strategic alliance will continue to pay attention to the progress of this policy and related research.