Evaluating Effects of EPO in Rodent Behavioral Assays Related to Depression
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Last Update: 2020-12-05
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Source: Internet
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Author: User
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The cytokine erythropoietin (EPO) is an important regulator of hematopoesis and has well-known tissue protective properties. Neurotrophic action is implicated as mechanistically important in the treatment of depression, and neurotrophic actions ofEPO suggest potential therapeutic utility of an EPO-like mechanism in depressive disorder. Rodent behavioral models that areresponsive to clinically used antidepressants as well as to neurotrophic compounds can be used to assess potential antidepressantproperties of EPO and EPO-like compounds. Rodent models described here are the forced-swim test (FST), a hyponeophagia testand the novel object recognition test. Each of these models provides different information and relevance to depression andeach can be tested with EPO and similar compounds.
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