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    Home > Active Ingredient News > Urinary System > "Evidence-based medicine" is convenient and practical! Do you know this prognostic indicator of renal cell carcinoma?

    "Evidence-based medicine" is convenient and practical! Do you know this prognostic indicator of renal cell carcinoma?

    • Last Update: 2023-01-07
    • Source: Internet
    • Author: User
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    Indicators that accurately predict the prognosis of cancer patients are critical
    for clinicians to develop the most appropriate treatment strategy and follow-up plan.

    Research background

    The Prognostic Nutrition Index (PNI), a novel method to assess a patient's immune and nutritional status based on serum lymphocyte count and albumin levels, has been used in several studies to predict the prognosis
    of patients with renal cell carcinoma (RCC).
    However, due to differences in sample size, patient characteristics, and other factors in existing studies, the effect of PNI on the prognosis of RCC still needs to be further explored
    To this end, Korean researchers conducted this meta-analysis to assess the diagnostic accuracy and application value
    of PNI as a prognostic factor in RCC based on available data.

    Study design

    Based on the systematic review and meta-analysis priority report entry (PRISMA) statement, the investigators conducted systematic and comprehensive searches of relevant literature in PubMed, Web of Science, Cochrane Library and EMBASE databases, constructed research questions according to PICO principles and screened
    The PNI value was calculated by formula× albumin concentration (g/dL) + lymphocyte count (/mm3) × 0.
    005, and its sensitivity, specificity, comprehensive receiver operating characteristic curve (SROC) and area under the curve (AUC)
    were evaluated.

    Study results

    The meta-analysis included 11 studies
    with a total of 7296 RCCs.
    Pooled analysis of PNI on the prognostic value of RCC showed a sensitivity of 0.
    733 (95% CI 0.
    802), specificity of 0.
    615 (95% CI 0.
    695), a diagnostic odds ratio (DOR) of 4.
    382 (95% CI 3.
    101), and an AUC of 0.
    72 (95% CI 0.

    1 Forest plot of PNI sensitivity and specificity for RCC prognostic value

    The results of subgroup analysis showed that the presence or absence of metastasis and the PNI cut-off value (≥50 vs <50) affected the diagnostic accuracy<b10> of PNI in RCC.
    Multivariate meta-regression showed significant differences in sensitivity and specificity between PNI and non-metastatic RCC groups (p=0.

    Table 1 Univariate and multivariate meta-regression analysis results

    Conclusion of the study

    This study shows that PNI shows good diagnostic accuracy as a prognostic indicator of RCC, especially in
    metastatic RCC.

    Editor's comments

    PNI is an economical, simple, efficient, and widely used predictor of nutritional and immune status and has been shown to correlate with
    the prognosis of a wide range of tumors.
    The findings further support that PNI can help clinicians predict clinical outcomes for RCC and warrant clinical rollout


    Shim SR, Kim SI, Kim SJ, Cho DS.
    Prognostic nutritional index as a prognostic factor for renal cell carcinoma: A systematic review and meta-analysis.
    PLoS One.
    2022 Aug 5; 17(8):e0271821.
    doi: 10.
    PMID: 35930538; PMCID: PMC9355260.

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