Excessive fructose intake can lead to intestinal leakage and fatty liver disease.

consumption of fructose, a sweetener common in the U.S. diet, can lead to non-alcoholic fatty liver disease (NAFLD), which is relatively abundant in the United States. But contrary to previous understanding, researchers at the University of California, San Diego School of Medicine report that fructose has an adverse effect on the liver only when it reaches the intestines, where sugar breaks the supersethic barrier and protects internal organs from gut bacterial toxins.in a study published August 24, 2020 in Nature Metabolism, the authors concluded that developing a treatment to prevent damage to the intestinal barrier could protect the liver from NAFLD, a disease that affects one-third of Americans., senior professor of pharmacology and pathology at the University of California, San Angeles, said: "NAFLD is the most common cause of chronic liver disease in the world. It can develop into more serious diseases such as cirrhosis, liver cancer, liver failure and death. "At the University of California, San Diego School of Medicine." These findings point to a way to prevent liver damage.Since the 1970s, Fructose consumption in the United States has soared and high fructose corn syrup (HFCS) has emerged as a cheaper alternative to sugar, widely used in processed and packaged foods, from cereals and baked goods to soft drinks. Several studies in animals and humans have linked increased HFCS consumption to the country's obesity epidemic and many inflammatory diseases such as diabetes, heart disease and cancer. However, the U.S. Food and Drug Administration currently regulates it similar to other sweeteners such as sucrose or honey, and recommends only moderate intake., however, the new study defines the specific roles and risks of HFCS in the development of fatty liver disease. "Fructose has a rich ability to induce fatty liver in fruit and dried fruit, which was known to the ancient Egyptians, who ate duck and goose dried fruit and made foie gras," Carlin said. Withof modern biochemistry and metabolic analysis, fructose is twice to three times more effective at increasing liver fat than glucose, a condition that triggers NAFLD. Moreover, the increase in soft drink consumption with HFCS corresponds to the explosive increase. In terms of NAFLD incidence. " is broken down in the human digestive tract by an enzyme called fructose kinase, which is produced by the liver and intestines. Using mouse models, the researchers found that excessive fructose metabolism in intestinal cells reduced the production of proteins that maintain the intestinal barrier, a tightly stacked layer of endoskin cells covered with mucus that prevents bacteria and microbial products, such as endotoxins, from leaking out of the intestinal wall. intestines and blood.Dr Jelena Todoric, lead author of thestudy, said: "Therefore, by breaking the barrier and increasing its permeability, excessive fructose intake can lead to chronic inflammation called endotoxinemia, as documented in experimental animals and children with NAFLD. "It's a visiting scholar at Karin Labs.study by Karin Todoric and colleagues at universities and institutions around the world found that endotoxins leaking into the liver cause an increase in inflammatory cytokines and stimulate the conversion of fructose and glucose to fatty acid deposits.it's clear that fructose plays a dirty role in the gut, and if you prevent damage to the gut barrier, fructose does little harm to the liver," kalin said. Scientiststhat feeding mice lots of fructose and fat can lead to particularly serious adverse health effects. "This mimics 95 percent of the relative fructose intake of U.S. teens, who get up to 21.5 percent of their daily calories from fructose each day, usually in combination with high-calorie foods like hamburgers and fries," Carlin said.interestingly, the team found that no adverse reactions were observed in mice when fructose intake was reduced below a certain threshold, suggesting that only long-term excessive fructose intake was harmful to health. The appropriate intake of fructose through normal fruit consumption is suitable., many processed foods contain HFCS, and most people can't estimate how much fructose they actually consume, " says Kaline, a technology expert. "While education and awareness-raising are the best way to address this problem, these findings offer hope for future treatment based on intestinal barrier recovery for those who have developed severe non-alcoholic fatty hepatitis (non-alcoholic fatty hepatitis). "
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