Experimental principle of synthesis of silver sulfadiazine powder and zinc sulfadiazine

Silver sulfadiazine is a sulfonamide/silver salt antibacterial drug, the chemical formula is C10H9AgN4O2S, white or off-white crystalline powder, easily deteriorated when exposed to light or heat
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For the treatment of burn wound infection, in addition to controlling infection, it can also promote wound drying, scab formation and promote healing
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After applying the medicine, it will gradually become dark brown when exposed to light
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Silver sulfadiazine powder is a short-acting sulfa drug for the treatment of systemic infections, with the antibacterial effect of sulfadiazine and the astringent effect of silver salts
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It has a broad antibacterial spectrum, and has good antibacterial activity against most Gram-positive and negative bacteria
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And can promote wound drying, scabbing and healing
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It is used to prevent and treat wound infection secondary to second- and third-degree burns or scalds
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Experimental principle for the synthesis of silver sulfadiazine and zinc sulfadiazine: Silver sulfadiazine is a sulfa drug applied to burn wounds, which has a strong inhibitory effect on Pseudomonas aeruginosa, and is characterized by maintaining the antibacterial effects of both sulfadiazine and silver nitrate
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In addition to being used to treat and control the infection of burn wounds, it can also make the wound dry, scab, and promote healing
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However, the cost of silver sulfadiazine is high, and it is easy to oxidize and deteriorate, so zinc sulfadiazine is made to replace silver sulfadiazine
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Silver sulfadiazine is a white or off-white crystalline powder, which is easily deteriorated when exposed to light or heat
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Insoluble in water, ethanol and chloroform
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Zinc sulfadiazine is white or off-white powder, insoluble in water, ethanol and chloroform
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Preparation of silver sulfadiazine: take 5 g of sulfadiazine and place it in a 50 mL beaker, add 20 mL of 10% ammonia water to dissolve
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Then weigh 3.
4g of AgNO3 weight and put it in a 50mL beaker, add 10mL ammonia water to dissolve, under stirring, pour the AgNO3-ammonia solution into the sulfadiazine-ammonia solution, a white precipitate is precipitated for a while, suction filtration, and distilled water is used to wash until no Ag reaction occurs, Get this product
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Dry and calculate the yield
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(2) Preparation of zinc sulfadiazine Take 5 g of sulfadiazine, put it in a 100 mL beaker, add dilute ammonia water (4 mL concentrated ammonia water is added to 25 ml water).
If there is insoluble sulfadiazine, add a small amount of concentrated ammonia water (about 1 mL) to make the sulfadiazine Pyrimidine is completely soluble
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Separately weigh 3 g of zinc sulfate, dissolve it in 25 mL of water, pour it into the above-mentioned sulfadiazine ammonia solution with stirring, stir for a while to precipitate a precipitate, continue stirring for 5 min, filter, wash with distilled water until there is no sulfate ion reaction (with 0.
1M chloride Barium solution check), dry, weigh, and calculate the yield
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Zinc sulfadiazine is a topical sulfa drug, which has the effects of both sulfadiazine and zinc, and has good antibacterial effects on most gram-positive bacteria, gram-negative bacteria, yeast and other fungi
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And it is not antagonized by p-aminobenzoic acid, and zinc also has bacteriostatic effect because it can destroy the DNA structure of bacteria
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A large amount of zinc is lost in the body of burn patients, and the use of this product can compensate for the loss and enhance the body's ability to resist infection and wound healing
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Note: When synthesizing silver sulfadiazine, all instruments need to be washed with distilled water
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