Experimental progress of Tangning Tongluo capsule, a new seedling medicine of Guizhou bailing

In April this year, when the news of Guizhou bailing's plan to buy the secret recipe of diabetes vaccine medicine came out, it was questioned At the end of the year, Guizhou bailing released a detailed "notice on the progress of research and development project of diabetes secret recipe" today, saying that Tangning Tongluo capsule has significant hypoglycemic effect and has the effect of improving glucose metabolism and lipid metabolism According to the announcement, Guizhou bailing immediately carried out preclinical research on the secret recipe of diabetes mellitus after signing the agreement on the cooperative development of Miao medicine with Yang Guoshun and Yang Ailong on April 15, according to which the capsule preparation was made, and entrusted the Institute of medicinal plants of the Chinese Academy of Medical Sciences to carry out relevant experiments on the project The experimental drug is tentatively named Tangning Tongluo capsule The experimental content is the effect of Tangning Tongluo Capsule on the hypoglycemic effect and diabetic complications of db / DB spontaneous diabetic mice The experimental results show that Tangning Tongluo capsule has significant hypoglycemic effect, can improve glucose metabolism and lipid metabolism, delay microvascular disease caused by diabetes, significantly improve fundus and kidney disease, and also has a certain improvement on the occurrence of diabetic heart disease In the aspect of improving macroangiopathy, the preliminary research results show that Tangning Tongluo capsule has a good inhibitory effect on the elevation of myocardial enzymes caused by diabetes, and the relevant pathological section detection is still in progress Tangning Tongluo capsule has a good hypoglycemic effect, can improve glucose tolerance, correct the disorder of glucose metabolism and lipid metabolism, delay the occurrence of microvascular complications, improve its symptoms, delay its course of disease, and has an important clinical application value in reducing the rate of disability, death and improving the quality of life of patients For the research prospect, Guizhou bailing said that Tangning Tongluo capsule is made of natural plant medicine, which has a good hypoglycemic effect in animal experiments It is necessary to do further confirmation research, and its function characteristics need to be further explored to meet the clinical positioning and drug demand Finally, the mechanism of action should be studied to clarify the way of action The next work plan is as follows: 1 Complete the preclinical toxicology experiment of Tangning Tongluo Capsule; 2 Carry out the preclinical research of new drugs on the basis of preclinical experiment; 3 At the same time of preclinical research of new drugs, the company will invest or cooperate with a third party to set up a specialized diabetes hospital or clinic nationwide, and actively carry out the application for medical institutions Preparation related work In fact, the above new drug is the secret recipe of Miao medicine purchased by Guizhou bailing from two natural persons Yang Guoshun and Yang Ailong in April this year At the time of acquisition, Guizhou bailing paid 5 million yuan to the above two natural persons, and the contract stipulates that Guizhou bailing has the right to buy out Party B's secret recipe at one time, with the maximum price not exceeding 100 million yuan The acquisition of Guizhou bailing was once questioned by the market, but now the results of the experiment undertaken by the Institute of medicinal plants of the Chinese Academy of Medical Sciences confirm the hypoglycemic effect of the drug, to some extent, it has made a release It is understood that with the increasing living standards of the people, the incidence rate of diabetes is increasing year by year With the advent of the aging population in China, the number of diabetic patients will continue to grow According to the data from Orient Securities, the overall market size of diabetes drugs in China in 2012 was about 27 billion yuan Compared with western medicine, traditional Chinese medicine has been difficult to obtain recognition of its hypoglycemic effect Therefore, if the drug is successfully developed, it will bring broad market space for Guizhou bailing However, the development of Tangning Tongluo capsule also has a long period and a large investment, and the research in each stage is risky.