Express complete remission rate of 83%, positive early clinical results of non-viral gene therapy for bladder cancer

▎WuXi AppTec content team editor enGene announced today that EG-70, an innovative non-viral gene therapy for local administration in mucosal tissue based on its proprietary technology platform, is used in the treatment of high-grade non-muscle infiltrates unresponsive to Bacille Calmette-Guerin (BCG) Positive results from a phase 1/2 clinical trial in patients with meningococcal bladder cancer (NMIBC)
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For more than 30 years, BCG immunotherapy has been the standard of care for NMIBC
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However, the 60% rate of disease recurrence and progression after BCG therapy suggests that patients with NMIBC still have an urgent unmet medical need
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Ultimately, most NMIBC patients who do not respond to BCG will undergo cystectomy, which removes the bladder at the same time as other surrounding organs
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enGene's DDX platform utilizes chitosan derivatives to deliver DNA or RNA into mucosal tissues
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EG-70 is a novel non-viral gene therapy that utilizes plasmids encoding two RIG-I agonists to stimulate the innate immune system, and IL-12 to stimulate the adaptive immune system
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By stimulating both branches of the immune system, intravesical administration of EG-70 produced significant tumor regression in a preclinical model of bladder cancer and induced potent immune memory
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Image source: 123RF clinical trial results show that EG-70 is safe and well tolerated, with encouraging clinical efficacy in patients with high-grade NMIBC in situ carcinoma who have failed BCG
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Of the 6 patients evaluable for efficacy at 3 months, 5 achieved complete remission (CR)
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This marks an 83% completion rate
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"The response observed with EG-70 is an important step toward the goal of avoiding cystectomy in NMIBC patients,
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said the clinical trial's principal investigator, Dr.
Gary Steinberg of NYU.
"If follow-up studies observe similar results, I believe this innovative intravesical monotherapy will have a meaningful impact on the lives of high-risk NMIBC patients
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” Reference: [1] enGene Announces Positive Preliminary Phase 1/2 Data with EG-70 in BCG-Unresponsive Non- Muscle Invasive Bladder Cancer.
Retrieved February 8, 2022, from https:// unresponsive-non-muscle-invasive-bladder-cancer-301477766.
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