Factors related to the hardness of tablet press

The factors related to the hardness of tablet press the hardness of tablet press is a problem often encountered during tablet pressing, which will affect tablet pressing and coating The loose tablet is mainly related to the particle quality and the operation of tablet press Particle quality is the key to pressing the tablets well, so the granulation process is particularly important for tablet quality The main factors affecting the quality of granules are as follows: first, the influence of the ingredients of traditional Chinese medicine For example, some Chinese herbal medicines contain a large number of fiber components Due to the large elasticity and small viscosity of these herbs, the particles are loose and the hardness of the tablets is low In practice, suitable solvents and methods can be used to extract and condense the effective ingredients in this kind of medicinal materials, and then prepare the granules, so as to reduce the elasticity of the granules, improve the compressibility, and then improve the hardness of the tablets; for the medicinal materials with a large amount of oil, the tablets can also easily lead to loose tablets If these oils are effective ingredients, they should be added during granulation An appropriate amount of absorbent (such as calcium carbonate) is used to absorb oil If the oil is an invalid component, it can be degreased by pressing or other degreasing methods to reduce the amount of granular oil and increase its cohesion, so as to improve the hardness of the film The second is the influence of the degree of comminution of traditional Chinese medicine If the fine powder of traditional Chinese medicine is not fine enough, the particles made of it are not strong in cohesiveness and easy to make the tablet loose Therefore, the powder should have a certain fineness, which is the premise of making particles and pressing tablets Third, the influence of adhesive and wetting agent Binder and wetting agent play an important role in granulation The selection and dosage of binder directly affect the quality of particles The choice of adhesives and humectants depends on the nature of the powder In the case of whole herbal powder tablet pressing, the adhesive with strong viscosity should be selected In the case of full extract tablet pressing, and in the case of more resin and mucus components in the extract powder, ethanol with a concentration of more than 80% must be selected as the humectant If the amount of binder is too small, the fine powder of particles will be too much, resulting in loose pieces The fourth is the influence of moisture in particles The moisture in the particles has a great influence on the tablet The proper amount of moisture can increase the plastic deformation of the brittle particles, reduce the elasticity, and is conducive to tablet pressing The over dried particles have large elasticity and small plasticity, so it is difficult to be pressed into tablets But if the moisture content is too high, it will make the tablet soft, and even stick or block the hopper, thus affecting the tablet pressing Therefore, the particle water content of each traditional Chinese medicine tablet must be controlled in a suitable range In addition, if the pressure is insufficient when the tablet press is running, the rotating speed of the tablet press is too fast, and the length of the punch is not uniform, the phenomenon of looseness of the tablet can be properly adjusted to increase the pressure or slow down the rotating speed, and the punch can be replaced If the pressure is enough and still loose, other reasons should be considered Do not impose pressure to avoid damaging the tablet press.