Fish oil is right and wrong

Guide: Fish liver oil is not omnipotted, small knowledge about its medication sharingWang Laobo recently found that cholesterol and triglycerides are elevated, but fear of statins are not safe to eatListen to people can eat a little deep-sea fish oil, can be ready to buy silly eyes, so many kinds of fish oil which fits?came with questions to Wang Laobo to consult the pharmacistSo, is fish oil as Wang Laobo expected to reduce blood lipids, reduce cardiovascular events without side effects? What's the difference between different fish oils?we'll talk about it today1, what is fish oil?fish oil generally refers to all fatty substances extracted from fat-rich fish (mostly deep-sea fish), the main therapeutic ingredients are omega-3 polyunsaturated fatty acids, including twenty-carbon pentaerate (EPA) and 22 carbon hexaparic acid (DHA)2, fish oil content is the same?currently global market-containing fish oil preparations containing omega-3 fatty acids are EPA/DHA combination synthes and EPA single formula products, the former see a variety of commercially available fish oil supplements, the latter mainly prescription drugsThe dosage specifications of commercially available fish oil supplements varynote that some fish oil labels high concentration, the total amount of oil in each capsule is more than 1000-2000 mg, and the purity of omega-3 fatty acids (including DHA and EPA) is not very high, many fish oil supplements of the total amount of omega-3 fatty acids only about 30%-50%In terms of appearance, high-purity fish oil color is lighter and more transparent3, fish oil can reduce blood fat?studies have found that omega-3 fatty acid triglycerides (TG) are the most visible, have beneficial effects on non-HDL (non-HDL), total cholesterol (TC) and very low density lipoprotein (VLDL), and do not raise ldl-density protein (LDL) compared to DHA, the reduction in TG was small in the intake of dietary or low-dose (1g/d) fish oil, while the tG decrease was significant after higher doses of fish oil (3-4g/d)However, because many fish oil supplements omega-3 fatty acids are not high purity, high-dose intake of these fish oils may also increase the intake of other components such as saturated fatty acids current consensus recommends high-purity fish oil (generally more than 85%) 4, fish oil can reduce the risk of cardiovascular events? studies have shown that elevated fasting TG is independently associated with cardiovascular events, and patients with good LDL control still have residual cardiovascular risk associated with elevated TG EPA and DHA in fish oil can reduce TG, but can only have an additional anti-atherosclerosis effect at higher doses study found that highly purified EPA (4g/d) significantly reduced the risk of cardiovascular death, myocardial infarction, stroke, unstable angina hospitalization, or coronary artery revascularization by 25 percent compared to placebo but previous studies of EPA/DHA combinations or fish oil supplements that may contain oxidized fatty acids and saturated fats have not found the same benefits for cardiovascular events as high-purified EPA Part of the reason may be related to different chemical structures of EPA and DHA, which have a more stable and expanded structure than DHA, which contributes to the stability of cell membranes and inhibits lipid oxidation and the formation of cholesterol domains 5, fish oil safety without side effects? fish oil is not without adverse reactions, in the compound preparation, gastrointestinal discomfort, indigestion, abnormal taste and other common, other but also rash, itching, liver enzyme elevated Fish oil has anti-thrombotic effect, can prolong the bleeding time, there are bleeding diseases should not be used, with other antithrombotic drugs need to pay attention to strengthen monitoring , people who are known to be allergic to fish or shellfish should also be careful 6, can fish oil replace statins? Although high-purity fish oil (EPA) shows the effects of reducing TG and reducing the risk of cardiovascular events However, because LDL cholesterol can promote the formation of atherosclerosis plaques, and the risk of atherosclerosis disease is most closely related, is the primary intervention target of lipid therapy, statins as the cornerstone of cholesterol-lowering drugs have important therapeutic significance, if no adverse reactions, need to adhere to long-term use current research evidence also recommends that high-purity fish oil can be used as an auxiliary treatment of statins in patients with clinically evaluated high TG