Fluidized bed granulation has obvious advantages, and pharmaceutical machinery companies are actively integrating more advanced technologies into their products

【Pharmaceutical network technical article】Drugs are indispensable or indispensable in modern people's lives, whether it is a stubborn disease or a headache and fever, it is inseparable from all kinds of drugs
.

The oral solid preparation is mainly based on tablets, capsules, granules, and more than 90% of the process of these dosage forms must go through the granulation process
.

Pharmaceutical machinery companies are actively integrating more advanced technology into fluidized bed granulation equipment (picture source: pharmaceutical network) The so-called granulation refers to the processing of powder, molten liquid, aqueous solution and other materials into granules of a certain shape and size, which is convenient for distribution, tableting, and convenient for patients to take
.

It is understood that the granulation method is mainly divided into dry granulation, wet granulation, fluidized bed granulation and so on
.

Compared with the traditional particle preparation technology, fluidized bed granulation (also known as one-step granulation method, boiling and drying granulation) has obvious advantages
in both cost accounting and production management.

First of all, in production management, fluidized bed granulation is a method
of mixing, granulating and drying the three processes of preparing granules in a closed container for one-time processing.

The technology makes full use of the clean air filtered by layers, the air is heated to a certain temperature, the heated air is blown up from the bottom of the solid powder sealed in the container through the low end of the equipment to achieve the boiling and rolling state, and the powder is repeatedly fluidized up and down by the fixed flow direction to achieve the purpose of
mixing.

The prepared adhesive is then sprayed through the spray gun so that it is fully bonded with the boiling and rolling powder in the air, forming small particles and drying
in the fluidized bed.

This makes the entire process of fluidized bed granulation is sealed, which can effectively control the flying of the material powder, which not only protects the production environment but also prevents cross-contamination, which is advocated by GMP
.

In fact, in order to strengthen the supervision and management of drug production and drug quality, to ensure the safety of patient medication, China has implemented the Good Manufacturing Practice (GMP) certification system, under this system, plant design and equipment configuration, water, ventilation and air conditioning systems, warehouse conditions, production management and quality management file system, organizational structure and other aspects are facing stricter requirements
.

In this context, the traditional granulation process obviously cannot fully meet the conditions of certified enterprises, therefore, fluidized bed granulation is widely recognized and applied
by pharmaceutical companies due to its advantages of high production efficiency, short cycle and GMP requirements.

It is worth mentioning that at present, a large number of equipment companies are continuing to innovate and upgrade more efficient new fluidized bed granulators
in order to further meet the needs of pharmaceutical companies.

For example, a company has developed a JOYNLHC100 laboratory fluidized bed granulator for GMP Pharmaceutical Engineering, which is a new type of high-efficiency drying equipment
.

It can be used with rocking pellet machines or high-efficiency wet hybrid granulators and has a wider fluidization range
than conventional horizontal XF boiling beds.

At present, it has been widely used in medicine, chemical, food, feed and other fields, for the drying
of wet particles and powdered materials.

In addition, there are also enterprises that have developed an LGL pharmaceutical fluidized bed granulator, which is very flexible in the production process of different products, and can be easily and quickly switched
according to different formulations and different application environments.

Its versatility ensures access to high-quality products, easy integration with other granulation equipment, and customer demands
for a high degree of automation.

Overall, fluidized bed granulation has many advantages
.

From the current point of view, pharmaceutical machinery companies are still making continuous efforts, actively conforming to new trends, trying new technologies, integrating more advanced and intelligent technologies into products, and developing more new fluidized bed granulation equipment, so as to escort the safe production of drugs, seek a way out for their own innovation and development, and contribute more to
the beautiful future of the pharmaceutical machinery industry.

Disclaimer: Under no circumstances does the information herein or the opinions expressed in this article constitute investment advice
to any person.