For the first time, the safe and efficient removal of tumor-related plateboards in tumor micro-environment was realized.

Plate platea plays a central role in blood clotting.
In tumor microenncts, tumor-related plateroids also have important functions in maintaining tumor vascular integrity: by secreting 5-serotonin (5-HT), plateboard fourth factor (PF-4), transformational growth factor (TGF)-beta and other particulate matter or directly adhere to the damaged blood vessels, tumor-related plateroids can maintain the integrity of the tumor's vascular endothelial, to prevent tumor internal bleeding.
special function of tumor-related plateboards provides a guarantee that tumors maintain their fast-growing properties so that tumor tissue does not necrosis due to inadequate blood and nutritional supplies.
The National Nanoscience Center of the Chinese Academy of Sciences, Yan Guangjun, has long been committed to the use of nanotechnology to target and regulate tumor blood vessels and tumor-related plateboard related research, recently, in the construction of environmentally responsive nano-drug vectors, to achieve safe and efficient tumor local plateboard removal, in order to enhance the tumor vascular EPR effect and chemotherapy drug targeting rich progress.
research by Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug union in tumours is published in the August 2017 issue of Nature Biomedical Engineering.
Professor Warren Chan, a professor at the University of Toronto in Canada, commented on the work as "making the case for more permeable".
This work constructs a lipid-copolymer hybrid nanodrule vector (pictured) with a nuclear shell structure, which has responsive properties to MMP-2 with enzyme-cut activity on the endotlysiop of tumor blood vessels, and realizes the targeted transport of antithroid antibodies (R300) to tumor tissue.
By specifically removing tumor-related plateroids, the vector causes the tumor vascular pores to increase, enhancing the EPR effect, which in turn promotes the penetration and abundance of the chemotherapy drug Amycin (Dox) in tumor tissue, effectively inhibiting the proliferation of breast and lung cancer cells in mice.
The study realized the safe and efficient removal of tumor-related plateboards in tumor micro-environment for the first time, which provided new techniques and ideas for enhancing the EPR effect of tumor blood vessels, and positively promoted the application of nanotechnology in tumor treatment.
, the study provides experimental basis for safe clinical application of anti-plateboard targeted therapy.
Suping, associate researcher at the National Nano Center, Zhang Yinlong, a doctoral student, and Wang Wei, an associate researcher, are co-authors of the work.
was supported by the National Natural Science Foundation of China, the Ministry of Science and Technology, the Chinese Academy of Sciences and the Beijing Municipal Science and Technology Commission.
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