Fouche cites cell's new study: The new coronavirus has mutated and becomemore contagious...
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Last Update: 2020-07-27
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Source: Internet
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Author: User
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On the afternoon of July 2, US chief infectious disease expert, white house health advisor Anthony Fauci, said the new coronavirus may have mutated and will be easier to spread, according to CNBC.at present, the study is identifying possible mutations and their implications.he added: "it may be a little controversial.".the virus mutates naturally, but scientists have previously said that they have observed only minor mutations in the new coronavirus, without any significant impact on its transmission or pathogenicity.the possible mutation mentioned by fudge is a new study published in cell on July 3, Beijing time. The research team led by Los Alamos National Laboratory found that the new coronavirus variant carrying the change of spike protein d614g amino acid has become the most common form of global pandemic.Image Source: cell's dynamic tracking of variation frequency shows that g614 shows a cyclical growth pattern at national, regional and urban levels.this transition can occur even in endemic diseases where the original d614 type was established before the g614 mutation.the consistency of this pattern is statistically significant, which indicates that g614 variant may have an adaptive advantage.Image Source: cell the team found that the g614 variant grew to a higher titer in the form of a pseudovirus.in infected individuals, g614 was associated with a lower RT-PCR cycle threshold, suggesting a higher viral load in the upper respiratory tract, but not related to the severity of the disease.these findings suggest important changes in understanding the mechanism of new coronavirus, and support continuous monitoring of spike mutations to help develop immune interventions.the team led by bette korber, a theoretical biologist at Los Alamos National Laboratory, wrote in the paper: "our global tracking data show that the g614 variant seems to reproduce faster in the nose, sinuses and throat than the d614, which also explains why it is more easily transmitted.studies have shown that g614 variants are 2.6 to 9.3 times more infectious than d614.this also highlights the importance of wearing masks and maintaining social distance.however, we have not found evidence that g614 affects the severity of the disease."the team tested samples from patients in Europe and the United States, sequenced the genome, and then compared it with the viral genome sequence publicly shared on gisaid.Image Source: cell researchers found that before March 1, g614 gene variants were rare outside Europe, but by the end of March, their frequency increased significantly worldwide.the researchers believe that the growth of this strain is often related to the implementation of large-scale home orders in an area.in an interview with Dr. Howard bauchner of the Journal of the American Medical Association, "the data show that there is a single variant that enables the virus to replicate better and may have a high viral load.we don't know if a person will get worse because of this.it just seems that the virus replicates better and may spread more easily."he added:" at present, researchers are still in the stage of trying to confirm this. All viruses evolve or mutate in their lifetime.RNA viruses like NCV can mutate faster than some other viruses because the enzymes needed to replicate do not have the ability to correct errors, which leads to faster mutation rates.the World Health Organization (who) has previously stated that not every mutation will lead to any meaningful changes in the behavior of the virus or its impact on humans.nevertheless, the organization has established a comprehensive gene sequence database to investigate any potential mutations.who and its global research team have been focusing on more than 60000 different coronavirus gene sequences collected from samples collected around the world.on July 2 local time, soumya Swaminathan, chief scientist of who, told reporters at a press conference that the "natural mutation" of the virus was expected.she explained that the virus has some more important "domains", such as the spike protein, which gives the new coronavirus its name.but she said: "if there are significant mutations in these domains, it may affect vaccine development., the official account, was hosted by the TOP101., a Microbiological Resource Center and a big data center of the Institute of Microbiology, Chinese Academy of Sciences. 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