Four commonly used drugs can reverse Alzheimer's disease in mice

Alzheimer's disease is the most common cause of dementia in Western society.

It is estimated that 24 million people worldwide suffer from this disease

In this study, scientists led by Dr.
Aloy described the three stages of Alzheimer's disease, namely the early, middle and late stages
.

For each stage, they analyzed animal behavior, studied the effects on the brain (especially the hippocampus at the tissue level), and performed molecular analysis to measure gene expression and protein levels

The method used allowed them to describe the development of the disease in a level of detail not known so far and compare it with healthy aging
.

"What we have observed is that although Alzheimer's disease has some accelerated aging characteristics, it is also affected by a completely different aging process," said Dr.

Chemical inspection: detecting the most promising molecules

After determining the characteristics of the disease, the scientists used the Chemical Checker, a computational tool developed by the same research team, to discover what is already on the market that can reverse this effect at the cellular level.
Drugs
.

The tool allowed them to identify a range of possible candidate genes and tested them in various mouse models of Alzheimer's disease

"Epidemiological studies have shown that people who regularly take anti-inflammatory drugs have a lower chance of developing Alzheimer's disease, but this is not related to a specific drug or mechanism
.

The results we published are the most promising, and we hope that They conduct further research because they may bring about a paradigm shift in the treatment of this disease," said Dr.

Early diagnosis of disease

In addition to paving a new research path for the treatment of Alzheimer's disease, the characteristics of the different stages of this condition announced in the study are conducive to early diagnosis
.

Diagnosis in the early stages of Alzheimer's disease (brain damage is still small) is one of the main research focuses on solving this disease and reducing symptoms

Article title

Identification and drug-induced reversion of molecular signatures of Alzheimer's disease onset and progression in AppNL-GF, AppNL-F and 3xTg-AD mouse models