Front Immunol: Hepatitis B surface antigen differs from hepatitis B virus DNA in the ability to divide the natural course stages of chronic hepatitis B virus infection

Background: Accurate definition of the natural course stages of chronic hepatitis B virus (HBV) infection and assessment of disease status are of great clinical significance

However, although HBV DNA is a key parameter in dividing the natural history stages, its effective thresholds, especially those for HBeAg-positive NSHA and SHA, remain controversial; Although hepatitis B surface antigen is recommended as a parameter for dividing the natural course stages, quantitative criteria have not been established

The role

ObjectiveTo quantify hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA in the natural history of chronic HBV infection have not been reasonably evaluated

Methods: 595 and 651 HBe-antigen positive patients and 485 and 705 HBeAg-negative patients were assigned to early and late cohorts

Results: In the early cohort, PHVR subcohort and PLVR subcohort, the area under the ROC curve of HBsAg and HBV DNA predicting HBeAg-positive significant hepatitis activity (SHA) was 0.

Figure 1 Scatterplot and loess regression curves

Table 1 Spearman correlation coefficients

Figure 2 ROC curves

Table 2 HBsAg, HBeAg, and HBV DNA predict the AUC

Table 3 HBsAg, HBeAg and HBV DNA predict the critical values of SHA and the corresponding diagnostic parameters

Table 4 Proportion of

Conclusion: Quantitative HBsAg and HBV DNA are valuable, but their abilities in dividing the natural stages of the disease are different

Original source:

Zhang Z, Lu W, Huang D, et al.