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Front Oncol: Based on the SEER database to compare the survival results of radical prostatectomy (PR) and radiotherapy (RT) for metastatic prostate cancer

 Last Update: 2021-12-04
 Source: Internet
 Author: User

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The efficacy of local therapy (LT) in patients with selective metastatic prostate cancer (mPCa) has been confirmed
.

However, the effect between different LT treatments is unclear

The efficacy of local therapy (LT) in patients with selective metastatic prostate cancer (mPCa) has been confirmed

The researchers screened mPCa patients who received RT or RP from 2004 to 2016 from the SEER database
.

Multivariate Cox proportional hazard analysis was used to evaluate the comparative risk of prostate cancer-specific mortality (CSM) and all-cause mortality (ACM) between LT

The researchers screened mPCa patients who received RT or RP from 2004 to 2016 from the SEER database

Before PSM, there were 203 cases in the RT group and 481 cases in the RP group

In the unmatched cohort, the Cox proportional hazards model showed no significant difference between the two groups of CSM or ACM (CSM: HR = 0.

Prognostic analysis

The Kaplan-Meier survival curve showed that the 10-year survival rates of the RP and RT groups before PSM were 70.
5% vs.
56.
7% for CSS and 55.
8% vs.
37.
0% for OS
.

After PSM, the 10-year incidence of CSS for RT and RT were 73.

The Kaplan-Meier survival curve showed that the 10-year survival rates of the RP and RT groups before PSM were 70.

Comparison of CSS and OS before and after PSM

Comparison ofCSS and OS before and after PSM

In the subgroup analysis, PR treatment in the T1-2 subgroup was associated with lower CSM (HR = 0.
42, 95%CI = 0.
17-0.
99, p = 0.
048)
.

In the subgroups of patients with GS≤7 and PSA≤20 ng/ml, the difference in CSM between the two groups was close to statistically significant (HR = 0.

In the subgroup analysis, PR treatment in the T1-2 subgroup was associated with lower CSM (HR = 0.

Subgroup analysis

In summary, studies have shown that for mPCa patients with good primary tumor characteristics, RP has a better survival outcome than RT, but not for more advanced patients
.

Studies have shown that for mPCa patients with good primary tumor characteristics, RP has a better survival outcome than RT, but not for more advanced patients

Original source:

Guo X, Xia H, Su X, Hou H, Zhong Q and Wang J (2021) Comparing the Survival Outcomes of Radical Prostatectomy Versus Radiotherapy for Patients With De Novo Metastasis Prostate Cancer: A Population-Based Study.
Front.
Oncol.
11: 797462.
doi: 10.
3389/fonc.
2021.
797462

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