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Front Oncol: Effects of esophagectomy and non-esophagectomy on the long-term prognosis of patients with stage T1 esophageal cancer

 Last Update: 2021-10-20
 Source: Internet
 Author: User

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Esophageal cancer is a malignant tumor that mainly originates from the esophageal epithelium.
Its morbidity and mortality rank seventh and sixth in the world, respectively
.

We can perform accurate T staging for patients with early esophageal cancer, but we cannot accurately diagnose lymph node metastasis before resection of esophageal cancer

Esophageal cancer is a malignant tumor that mainly originates from the esophageal epithelium.

The study collected SEER database of patients with stage T1 esophageal cancer from 2005 to 2015 and divided them into two groups: esophagectomy and non-esophagectomy
.

The esophageal cancer-specific survival (ECSS) rate and overall survival (OS) rate were compared between the two groups

The study collected SEER database of patients with stage T1 esophageal cancer from 2005 to 2015 and divided them into two groups: esophagectomy and non-esophagectomy

A total of 591 eligible patients with stage T1 esophageal cancer were included in the study, including 275 in the non-esophagectomy group and 316 in the esophagectomy group

The ECSS of the non-esophagectomy group was better than that of the esophagectomy group (HR=2.

ESCC and OS

The COX proportional hazard regression model was used to explore the risk factors that affect the prognosis of patients with T1 esophageal cancer
.

Univariate COX regression analysis found that race, grade, histology, AJCC staging, and treatment have statistically significant effects on the ESCC rate

The COX proportional hazard regression model was used to explore the risk factors that affect the prognosis of patients with T1 esophageal cancer

multi-factor analysis

Among patients with stage T1a esophageal cancer, the difference in survival between the non-esophagectomy group and the esophagectomy group was not statistically significant, regardless of ECSS (HR=1.
84; 95%CI, 0.
86-3.
91; P = 0.
11) or It is OS (HR = 0.
87; 95% CI, 0.
52-1.
47; P = 0.
60)
.

ECSS and OS in T1a patients

However, in T1b patients, there was no significant difference in the ESCC rate between the non-esophagectomy group and the esophagectomy group (HR=0.
71; 95%CI, 0.
33-1.
55; P = 0.
39), but the OS of the non-esophagectomy group Worse (HR = 0.
48; 95%CI, 0.
26-0.
91; P = 0.
01)
.

However, in T1b patients, there was no significant difference in the ESCC rate between the non-esophagectomy group and the esophagectomy group (HR=0.

ECSS and OS in patients with T1b

In summary, studies have shown that non-esophagectomy is a safe and effective option for patients with T1a stage esophageal cancer, but for T1b patients, esophagectomy is still a better treatment
.

Studies have shown that non-esophagectomy is a safe and effective option for patients with stage T1a esophageal cancer, but for T1b patients, esophagectomy is still a better treatment
.
Studies have shown that non-esophagectomy is a safe and effective option for patients with stage T1a esophageal cancer, but for T1b patients, esophagectomy is still a better treatment
.

Original source:

Pan L, Liu X, Wang W, Zhu L, Yu W, Lv W and Hu J (2021) The Influence of Different Treatment Strategies on the Long-Term Prognosis of T1 Stage Esophageal Cancer Patients.
Front.
Oncol.
11:700088.
doi: 10.
3389/fonc.
2021.
700088

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