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Responsible Editor: Food Science
On March 21, 2022, the international SCI academic journal "Frontiers in Nutrion" (Frontiers in Nutrition) published the latest research paper "Drinking Natural Mineral Water Maintains Bone Health in Young Rats With Metabolic Acidosis (Drinking Natural Mineral Water Maintains Bone Health in Young Rats With Metabolic Acidosis)" Mineral water helps relieve metabolic acidosis in young mice and enhances bone health)
With the improvement of people's living standards, the diets of the Chinese population, especially adolescents and children, gradually tend to be Westernized.
Natural mineral water provides a steady, continuous supply of minerals (such as calcium, magnesium, and bicarbonate) to the body, gently relieves the body's acid load, and ultimately promotes bone health
experimental design
This study established a metabolic acid load model in adolescent rats, and conducted a drinking intervention experiment with three types of bottled water for 16 consecutive weeks after randomization
Experimental results
The results show that: (1) Compared with drinking PW (purified water), natural mineral water Bic-NMW and Sul-NMW can reduce the excretion of urine net acid, and increase the femoral bone mineral density, growth plate width and cortical bone trabecular area value.
Research suggests that drinking natural mineral water, especially one that is naturally rich in bicarbonate, can effectively improve the bone health of young rats
1.
Figure 1 Acid-base balance in rats
(A) Arterial pH in rats before (13 weeks) and after (16 weeks) acid loading, (B) Net acid excretion in acid-loaded rats (16 weeks)
2.
Fig.
(A) Representative micro-CT 3D micro-computed tomography images of the femur, (B) bone mineral density, (C) bone volume/total integral fraction, (D) bone surface/bone volume fraction
3.
Figure 3 Histopathological changes of rat femur after acid loading(A) Representative whole-slide images of femur stained with hematoxylin and eosin, (B) cortical bone area, (C) cortical trabecular area, (D) cancellous medullary cavity area, (E) growth plate width, (F) Width of hypertrophic cartilage, (G) Width of proliferative zone
Fig.
(A) Immunostaining of osteoclasts with TRAP (40×), (B) number of osteoclasts
4.
Figure 5 Changes of bone metabolism-related indexes in rats after acid loading
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