Fudan University reveals a new mechanism for the development and regulation of colon cancer

at fudan University's Institute of Biomedical Research in Molecular and Cell Biology revealed the important regulatory role of cytokine endopitin, which regulates vascular contraction, on the development of colon cancer through downstream Hippo-YAP/TAZ signaling path paths. The findings were published
Cancer Research.
is a malignant tumor of colon tissue, which is often associated with colorectal cancer and is therefore called colorectal cancer. Colorectal cancer is the second most common type of cancer in the world, resulting in the top three causes of death. Compared with normal tissue, colon cancer cases and cells are highly expressed endoderin-like body ETAR, endopisin and its GPCR family of endopitin-like subjects composed of signaling path paths can promote cell growth, cell survival and cell migration processes, and thus induce the occurrence of tumors, but the signal transduct path within their cells has not yet been fully clarified.
the study, the researchers found that endopitin signals are important upstream signals in the Hippo path, which activates YAP/TAZ transcription co-activation factors through endopisin-like and coupled G proteins, and promotes transcriptional expression of downstream genes such as CTGF and CYR61.
" signaling system has an important role in promoting the growth of colon cancer cells, migration and allogeneic transplantation of colon cancer tumors. Professor Yuan Haisin, one of the co-authors and head of the study, said the study sheds light on the important role of Hippo-YAP/TAZ signaling pathlines in mediated endopisin signaling, as well as the molecular mechanisms between endoderpiser activation and colon cancer, providing potential new diagnostic and therapeutic targets for colon cancer treatment and laying the foundation for the study of Hippo signaling path molecular inhibitors. (Source: Science Network Huang Xin)