Gao Fu/Shi Weifeng Science published an opinion article: Attention must be paid to the new H5N8 avian influenza virus, which can cause human infection

Since 1878, many suspected HPAIV outbreaks have been recorded worldwide.

However, it was not until 1959 that records from Scotland first confirmed an outbreak of HPAIV in poultry caused by influenza A H5N1 subtype.

Since the end of 2019, highly pathogenic H5Ny avian influenza has frequently occurred in birds in Eurasia and Africa.
Eurasia and Africa are experiencing a new wave of highly pathogenic H5Ny avian influenza.

Recently, Professor Shi Weifeng, Director of the Institute of Pathogenic Biology, School of Basic Medical Sciences, Shandong First Medical University, and Director of the Laboratory of Etiology and Epidemiology of Newly Emerging Infectious Diseases in Shandong Province, and Gao Fu, Director of the Chinese Center for Disease Control and Prevention, and Academician of the Chinese Academy of Sciences ”Magazine published an opinion article, outlining the prevalence and evolution of the global H5 subtype avian influenza virus.

Shi Weifeng is the first author of the article, and Shi Weifeng and Gao Fu are co-corresponding authors.

Shi Weifeng and Gao Fu specifically pointed out in the article that the H5N8 avian influenza virus is pandemic in Asia, Europe and Africa, and it has become an important issue affecting global poultry breeding and wildlife safety.

At the same time, the newly issued H5N8 avian influenza virus can cause human infection, which has become a public health issue that deserves attention and must be taken seriously.

The authors pointed out that especially in the spring of 2020, the 2.
3.
4.
4b branch H5N8 avian influenza virus caused multiple outbreaks in Central and Eastern Europe.

In the autumn and winter of 2020, another outbreak of H5N8 avian influenza occurred in Eurasia.

In October 2020, many European countries including Denmark, Germany, Ireland, the Netherlands and the United Kingdom reported a new wave of H5N8 infections in poultry and wild birds.

At the same time, H5N8 avian influenza outbreaks have also occurred in poultry and wild birds in the Middle East (Israel) and East Asia (Japan and South Korea).

South Korea and Japan have killed more than 20 million poultry for this purpose.

Up to now, the areas affected by the H5N8 bird flu epidemic are still increasing, and at least 46 countries have reported the H5N8 highly pathogenic bird flu epidemic.

What has aroused the vigilance of the outside world is that in December 2020, Russia reported that 7 farm workers were infected with the H5N8 avian influenza virus.
This is the first report of human infection with the H5N8 avian influenza virus in the world.

The HA gene of the H5N8 avian influenza virus that infects humans also belongs to the 2.
3.
4.
4b branch.

The authors stated in the article that due to the long-distance migration of wild birds, the innate recombination ability of avian influenza virus (AIV), the enhancement of human receptor binding ability and the continuous variation of HPAIV antigen, the global spread and potential risk of H5N8 AIV It poses a serious threat to poultry farming, wildlife and global public health.

The authors therefore point out that monitoring of HPAIV in poultry farms, live poultry markets, and wild birds should be restored to pre-COVID-19 pandemic or higher levels.

In addition, the transmission, pathogenicity and antigenicity of 2.
3.
4.
4b H5N8 need to be further evaluated.

If there is obvious antigenic variation, HPAIV should be updated in time.

It should also be considered to reduce small-scale family-based poultry farming, increase large-scale high-standard modern poultry farming, and strengthen the management of the live poultry market, which will help reduce the spread of HPAIV and potential human infections.

The authors also emphasized that education and publicity are also very important, including strengthening personal protection measures during the flu season, staying away from wild birds, and avoiding hunting and eating wild birds.

This research was funded by the National Science and Technology Major Project (2018ZX10101004), Shandong First Medical University Academic Promotion Plan (2019QL006) and Shandong Taishan Scholars Project.

Article link: https://science.
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