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    Home > Medical News > Medical Science News > Gastrodin may become a low-toxic and high-efficiency fatty liver treatment drug

    Gastrodin may become a low-toxic and high-efficiency fatty liver treatment drug

    • Last Update: 2021-07-30
    • Source: Internet
    • Author: User
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    Gastrodin may become a low-toxic and high-efficiency fatty liver treatment drug




    Gastrodin may be a low-toxic and high-efficiency fatty liver treatment drug Gastrodin may be a low-toxic and high-efficiency fatty liver treatment drug

     

    On July 23, Ding Yi's research group, associate professor of College of Animal Science and Technology of Huazhong Agricultural University and School of Veterinary Medicine, published the latest research results online in Hepatology
    .
    By screening natural compounds for the treatment of steatohepatitis, the team found that gastrodin has good safety and anti-fatty hepatitis effects, and further explored the mechanism of gastrodin

    .

    Hepatology

    Fatty liver is one of the common metabolic diseases in animals (such as cows, chickens, cats, etc.
    ) and humans, which can cause fatty hepatitis and cirrhosis in severe cases

    .
    Despite the rapid development of modern medicine, people have made great progress in discovering its therapeutic targets, but there are no approved effective therapeutic drugs

    .

    In this study, mice were fed a high-fat diet, high-fat and high-cholesterol, established fatty liver and steatohepatitis models, and treated with gastrodin
    .

    Compared with the control group, the liver weight, liver and serum triglyceride and cholesterol content, serum alanine aminotransferase and aspartate aminotransferase activities of gastrodin-treated mice were significantly reduced, lipid accumulation in liver cells and inflammation The sexual response was significantly alleviated, and genes related to lipid accumulation, inflammation and fibrosis were significantly down-regulated
    .

    Gene enrichment analysis found that gastrodin mainly activates AMPK (adenylate activated protein kinase) pathway
    .
    Further studies have confirmed that gastrodin mainly reverses steatohepatitis through the AMPK pathway

    .
    The study screened out low-toxic and high-efficiency therapeutic drugs for steatohepatitis and discovered its new targets

    .

    This research was funded by the National Natural Science Foundation of China
    .
    (Source: China Science News Li Chen)

    Related paper information: https://doi.
    org/
    10.
    1002/hep.
    32068

    https://doi.
    org/
    10.
    1002/hep.
    32068
    https://doi.
    org/

     

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