Gastrointest Endosc: Metal stents covered with silicon membranes with integrated silver particles prevent malignant biliary obstruction.

Membrane-covered self-puffing metal stents (SEMSs) have been developed to extend the smoothness of stents by reducing tissue growth or tumor growth.
, the stent is blocked due to the formation of biofilms on the inner surface of the membrane, which weakens its effectiveness.
a single-center trial study evaluated the efficacy and safety of SEMSs covering silicone membranes containing integrated silver particles (Ag-P) in malignant far-end biliary obstructions, published online in Gastrointest Endosc.
study included 24 patients who received SEMS for malignant biliary far-end obstruction.
results were technical success rate, clinical success rate, adverse events, stent flow rate and survival rate.
results showed that the technical success rate and the clinical success rate were 100% and 91.7% respectively (22 out of 24 cases).
of early and late adverse events were 22.7% and 36.4%, respectively.
re-intervention rate was 27.3% (6 out of 22 cases).
only one case involving stent failure was associated with stent blockage.
of the bracket is 179 days.
no serious adverse events or deaths associated with stents or Ag-P occurred during follow-up.
the serum and urine silver concentrations before, during and after the scaffolding was placed before and after 32 weeks.
serum and urinary silver concentrations were 3 μg/L (3 ppb) and 5 ?g/L (5 ppb) respectively.
, the results show that SEMSs covering silicon membranes containing integrated Ag-Ps may be effective and safe for malignant far-end biliary obstruction.
use of this new bracket may result in fewer stent dysfunctions associated with bracket blockages.
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