Gene site variation: What is the link between tanning and skin cancer?

A genetic study published online today in the British journal Nature Communications shows that exposure to sun exposure to sun burn rather than tanning is a major risk factor for skin cancer, and a recent genome-wide association study (GWAS), involving 176,678 people, has identified additional genetic sites that may be associated with tanning reactions.
tanning is the skin under the action of ultraviolet light to produce melanin, resulting in darkness of skin color phenomenon, while sunburn is normal skin after exposure to an acute inflammatory reaction, manifested as erythema, edema, edema, edema and pigmentation, desafor.
previous studies have found that the relationship between tanning and genetic factors is strong.
and whether a person gets sunburned or tanned after exposure to the sun depends, at least in part, on the mutation of a particular gene site.
to better understand how a person's genetic makeup determines how it reacts to the sun, Mario Falch, a researcher at King's College London, and colleagues analyzed the genetic variation of a large group of subjects.
some of the subjects self-reported never tanning or just occasionally tanning and sunburning (46,768), while others said they would get sunburn without sunburn (74,528).
, the researchers conducted a repeated study of 55,382 individuals, and found genetic variation sifts at 10 genetic sites that had not previously been associated with the tanning response.
researchers further found that some variations at AGR3/AHR sites associated with lower tanning risk may also increase the risk of skin cancer.
team noted that the findings, based on self-reports of tanning and skin cancer (i.e. questionnaire responses), may be reporting bias, and further research is needed to confirm the possible role of the identified genetic variants in tanning and skin cancer.
.