Gospel! New research has shown that perinatal tissue stem cells can significantly promote burn healing

In November 2020, the well-known translational medicine journal Regenerative Engineering and Translational Medicine published online a regeneration study of the umbilical cord-filled stem cells (PRPCryogel-MSCs) encapsulated in platelet-rich plasma cryogel (PRPCryogel-MSCs) in platelet-rich plasma cryogel (PRPCryogel-MSCs).
, the pluripotent plateplate plasma combined interstumined stem cell group had higher wound closure rates on the 21st and 28th days compared to the control group.
On the 14th day, the angiogenesic rate was highest in the interstumined stem cell group and in the plateplate plasma freezing gel combined with the intersupcharged stem cell group, and on the 28th day, the cortogenic regeneration rate of the plateast plasma plasma combined with the intersupergenated stem cell group increased.
in short, the combination of umbilical cord-filled stem cells with plateboard plasma-rich frozen gels could be considered a promising method for burn healing.
Photo Source Literature: Skin tissue trauma and perinatal tissue source stem cell skin is the outerst layer of the human body structure, but also the largest organ of the human body, the skin has a protective effect on the body, but also the nervous system sensor and effector.
addition, the body's metabolism, immune system are inseparable from the skin's participation.
, however, people inevitably cause skin damage in their daily lives, including bruises, cuts, and burns.
Once the skin tissue is damaged to form a large-scale wound, it will have a significant impact on the body, and the trauma repair process of severe and even life-threatening skin is very complex, requiring a variety of cells and tissues to work together, including cell proliferation, migration, substrate synthesis, skin contraction and the synergy of growth factor-related signaling processes.
of the wound determines the treatment, including wound, skin graft, etc.
For large-scale burns and third-degree burns, the most common treatment is to remove the burn tissue and perform an autobiographic skin transplant as early as 24-72 hours after injury, but if it is a serious injury, due to a lack of the part of the body, resulting in the lack of self-skin transplant conditions, you need to choose a foreign transplant or dermatogen replacement.
these treatments often cause secondary injuries and are expensive.
image source literature, including the placenta and umbilical cord.
contains multiple types of stem cells in perinatal tissue, and the number is very large, interstate stem cells are one of them.
The umbilical cord and placenta-filled stem cells have some unique advantages, such as lower immunogenicity, and easy separation and high purity, in addition to having the common characteristics of amplification ability and multi-way differentiation potential.
stem cells from perinatal tissue sources have been shown to play an important role in the field of surface repair.
perinatal tissue-filled stem cells for diabetic foot patients to bring evangelical diabetic foot is caused by diabetes lower limb vascular lesions, vascular endothial function is severely damaged, the blood supply to the lower extremities is insufficient resulting in the wound surface can not be healed a disease.
early onset of the disease through interstupling stem cells, skin growth factors and a variety of biologically active ingredients intervention, it is expected to improve the local blood supply and tissue regeneration and skin healing of the wound surface.
based on this, the domestic researchers treated 100 patients with type 2 diabetic skin ulcers for routine treatment and inter-cord charge stem cell transplantation, respectively, to observe and compare the invasive healing time and healing effect of the two treatments.
after stem cell therapy, the healing time was shortened from 50 days to 22 days, and the cure rate reached 70%, with an overall effective rate of 94%, significantly higher than that of patients treated with conventional treatment.
Perinatal tissue-filled stem cells to save burn patients in China and the research team selected 82 cases of II.degree burns aged 15 to 65 years old as the subject of the study, divided all patients into two groups, respectively, to receive umbilical cord interstity charge stem cell transplantation and routine burn treatment.
results showed that three months after receiving the umbilical cord interstumin stem cell transplant, the expression of the growth factor of the skin cell and the growth factor of the endovascular cortical was more obvious, and the number of new blood vessels was higher.
, compared with conventional treatment, inter-umbilical cord charge stem cell transplantation is more effective in patients with II. degree burns.
Perinatal tissue interstitial interstitial stem cell exosome is expected to become a new therapeutic vector interstitial stem cell transplantation treatment to promote wound healing is a complex process, some studies have revealed that the umbilical cord contains a large number of α-2-pythrin (alpha2M) exosome may be the main component to promote wound healing.
researchers treated four of the eight black mice in the study with exosomes and four with other treatments for seven days after treatment.
wound healing ability was significantly enhanced after exosome treatment, the number of regenerative cells at the wound site was more, and collagen deposition increased significantly.
this study provides the possibility for clinical study of the treatment of skin trauma by inter-umbilical cord-filled stem cell exosome, and is expected to be an ideal alternative treatment.
currently, research on the healing of perinatal tissue in the wound is in full swing, including preclinical and clinical studies.
, interstate stem cells from perinatal tissue sources show encouraging results in terms of anti-inflammatory and anti-apoptosis, progress in preventing burn wounds, and improved wound healing.
, local applications are by far the most widely used route of drugation in preclinical studies, improving the outcome of acute injuries and reducing the need for innard skin grafts.
a larger randomized controlled trial to study the safety and effectiveness of stem cells in treating burns in the future.
the therapy will be a major breakthrough in the field of wound healing.
references, Afzali L, Mirahmadi-Babaheydari F, Shojaei-Ghahrizjani F, et al. The Effect of Encapsulated Umbilical Cord-derived Mesenchymal Stem Cells in PRPCryogel on Regeneration of Grade-II Burn Wounds. Regenerative Engineering and Translational Medicine, 2020: 1-11.Wang Y, Chen X, Cao W, et al. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nature immunology, 2014, 15(11): 1009.He Yuqing. Clinical Study of Inter-umbilical Cord Filled Stem Cells for the Treatment of Type 2 Diabetic Skin Ulcers , China Coal Industry Medical Journal, 2014, 17 (04): 532-534. Cai Denan, Chen Fei, Wang Musheng. Effects of inter-cord charged stem cell transplantation on the expression of newborn granulated tissue EGF and VEGF in burn patients. Bakhtyar N, Jeschke M G, Herer E, et al. Exosomes from acellular Wharton's jelly of the human umbilical cord promotes skin wound healing. Stem cell research & therapy, 2018, 9(1): 193.