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    Home > Food News > Food Articles > Grape seed extract improves the colon injury induced by PhIP in rats by regulating the intestinal flora, lipid metabolism and NF-κB signaling pathway

    Grape seed extract improves the colon injury induced by PhIP in rats by regulating the intestinal flora, lipid metabolism and NF-κB signaling pathway

    • Last Update: 2021-03-17
    • Source: Internet
    • Author: User
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    Editor in charge: Food Science
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    Recently, the team of Professor Zhang Yan and Professor Wang Shuo of Nankai University published an online article titled "Grape seed extract ameliorates PhIP-induced colonic injury by modulating gut microbiota, lipid metabolism, and NF-κB signaling pathway in rats" in the Journal of Functional Foods.
    This study explored the protective effect and mechanism of grape seed extract (GSE) on colon injury caused by short-term exposure to PhIP.
    Professor Zhang Yan and Professor Wang Shuo of Nankai University are the corresponding authors of this article.

    Focus:

    Grape seed extract (GSE) improves 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (2-Amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine, PhIP) induced oxidative stress and DNA damage.

    GSE improves the intestinal flora disorder caused by PhIP.

    GSE improves lipid metabolism disorders caused by PhIP.

    The NF-κB signaling pathway is involved in the process of colon protection.

    Summary

    2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is rich in protein A common carcinogen produced during thermal processing of foods.
    Xiuli Zhao of the State Key Laboratory of Food Nutrition and Safety of Tianjin University of Science and Technology, Yan Zhang and Shuo Wang of Nankai University School of Medicine, and others discussed the protection of grape seed extract (GSE) on colon injury induced by short-term exposure to PhIP Function and its mechanism.
    Wistar rats were randomly divided into control group, GSE only group (GSE), PhIP group (PhIP) and GSE prevention group (GPhIP).
    In the GPhIP group, the rats were fed a diet supplemented with GSE for 2 weeks before PhIP was administered.
    GSE can significantly improve PhIP-induced oxidative stress and colonic DNA damage.
    In addition, GSE effectively maintains the homeostasis of the intestinal flora, especially to prevent PhIP-mediated reduction in the abundance of lactic acid bacteria.
    Stool metabolome and colonic transcriptome analysis showed that GSE significantly improved PhIP-induced colon damage by regulating lipid metabolism.
    It is worth noting that the NF-κB signaling pathway is involved in the process of prevention and protection.
    Therefore, it is recommended to use GSE as an effective dietary supplement to prevent the harm of PhIP in the body.

    Corresponding author profile

    Professor Zhang Yan

    Zhang Yan, first-level candidate of 131 Innovative Talent Project, PhD supervisor

    1.
    Educational background

    1989.
    09-1993.
    07, College of Agriculture, Hebei Agricultural University, undergraduate

    1994.
    09-1997.
    07, Huazhong Agricultural University, College of Food Science and Technology, Master

    2001.
    09-2005.
    04, Food Engineering and Biotechnology, Tianjin University of Science and Technology, PhD

    2.
    Work experience

    1997.
    07-1999.
    10, Assistant Professor, Tianjin University of Science and Technology

    1999.
    11—2004.
    10, Lecturer, Tianjin University of Science and Technology

    2004.
    11-2009.
    10, Associate Professor, Tianjin University of Science and Technology

    2009.
    11—2018.
    01, Professor of Tianjin University of Science and Technology

    2009.
    09-2010.
    03, US FDA Food Safety and Technology Research Center, visiting scholar

    2018.
    01—present, Professor of Nankai University

    3.
    Research direction

    1.
    The production mechanism of health hazards in the process of food processing, the mechanism of hazard action and dietary nutrition intervention; 2.
    The quality and safety control technology of the food processing process; 3.
    The new technology of rapid food safety detection.

    Professor Wang Shuo

    Wang Shuo, winner of the National Science Fund for Distinguished Young Scholars, a doctoral supervisor, a leader in scientific and technological innovation of the National "Ten Thousand Talents Program", enjoys a special allowance from the State Council.
    He is an expert in the "Eleventh Five-Year" National Science and Technology Support Program "Key Food Processing Technology Research and Industrialization Development" expert group expert, "Twelfth Five-Year" National High-Tech Research and Development Plan ("863" Plan), food manufacturing in the field of modern agricultural technology Experts from the expert group on topics related to safety technology, chairman of the Youth Science and Technology Committee of the Chinese Society of Food Science and Technology Currently serving as a member of the editorial board of LWT-Food Science and Technology, Journal of Agricultural and Food Chemistry and other academic journals.
    As the first completer, he won 1 second prize of National Science and Technology Progress Award and 1 first prize of Tianjin Science and Technology Progress Award.

    Research direction (including undertaking research projects):

    1.
    Research and development of small molecule immunoassay theory and new detection technology; 2.
    "Bionic antibody" synthesis and reaction mechanism and alternative biological antibody immunoassay theory and detection technology; 3.
    Research and development of food processing quality and safety control technology ; 4.
    Food safety risk assessment.

    The article "Grape seed extract ameliorates PhIP-induced colonic injury by modulating gut microbiota, lipid metabolism, and NF-κB signaling pathway in rats" was published online in the Journal of Functional Foods.

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