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As the saying goes: People are what they eat.
Different eating habits create different intestinal microbiomes (i.
e.
intestinal flora).
As we all know, this intestinal ecosystem called the "second brain" is closely related to various human diseases, such as cancer, cardiovascular disease, type 2 diabetes, obesity and hypertension, as well as Alzheimer's and mental diseases.
.
In other words, the gut microbiome directly affects the balance of pro-inflammatory and anti-inflammatory responses in the intestine.
Recently, in a study published in "Gut", a research team led by the University of Groningen in the Netherlands revealed the interaction between diet, intestinal flora and its induction of intestinal inflammation.
Certain dietary patterns influence the inflammatory response in the intestine through pro-inflammatory or anti-inflammatory mechanisms.
Changing eating habits will help prevent intestinal inflammation in some chronic diseases.
It is known that the imbalance of the intestinal flora is related to more and more inflammatory diseases.
In addition to the local immune response, it also affects the systemic immune response and is related to more and more immune-mediated inflammatory diseases, including diabetes and arthritis.
And systemic lupus erythematosus.
However, it is still unclear whether specific foods or eating patterns will affect the composition of the gut microbiome, leading to inflammation in the gut.
To find out, the researchers looked at the interaction between the daily diet, gut microbiome, and gut inflammation of 1,425 participants.
Including 205 people with Crohn's disease (CD), 331 people with ulcerative colitis (UC), 223 people with irritable bowel syndrome (IBS), and 871 healthy individuals.
Each participant provided a stool sample for metagenomic sequencing and inflammatory marker testing.
They also filled out a food frequency questionnaire to quantify the average daily nutrient intake.
The researchers aggregated their diets into 25 patterns (see picture below).
After analysis, the researchers determined 38 associations between eating patterns and specific flora.
In addition, in a meta-analysis of healthy individuals with Crohn’s disease, ulcerative colitis, and irritable bowel syndrome, 61 foods and nutrients are related to 61 bacteria and 249 metabolic processes.
Researchers have found that processed foods and animal-derived foods are always associated with relatively high abundance of "opportunistic" bacteria (enemy bacteria) species, including Firmicutes and certain bacteria of the genus Ruminococcus (Ruminococcus sp.
.
), they are all involved in pro-inflammatory activities.
On the other hand, plant foods such as nuts, fruits, vegetables, and grains are related to "friendly" bacterial species, such as Faecalibacterium sp.
These beneficial bacteria can produce short-chain fatty acids (SCFA), which can ferment fiber and pectin into ethyl acetate.
Salt and butyrate have anti-inflammatory and protect the integrity of intestinal cells.
Coffee intake is also associated with higher abundance of Oscillibacter and increased glycolytic pathways, while edible cheese and yogurt and other fermented dairy products have been shown to be closely related to the abundance of lactic acid bacteria, butanediol and peptidoglycan synthesis Related.
The food groups of bread, beans, fish, and nuts are consistently associated with the relative abundance of "opportunistic" bacteria and lower pro-inflammatory activity.
The fast food group diet consisting of meat, French fries, mayonnaise, and soft drinks was associated with "enemy bacteria" among all study participants, such as Clostridium, Coprobacillus and Lachnospiraceae ).
In the absence of cellulose, these bacteria will turn to the mucus layer of the intestine for food, causing the integrity of the intestine to be eroded.
The colonic mucus layer serves as a barrier to isolate the intestinal contents and epithelial cells, and is also the first barrier.
Its structural and functional integrity play a very important role in the health of the human body.
Long-term intake of alcohol and sugar is associated with a higher quinone synthesis pathway, which is consistent with the increase in quinone synthesis in the intestinal tract of patients with inflammatory bowel disease (IBD).
To sum up, the large intake of animal-derived foods, processed meats, alcohol and sugar is related to the pro-inflammatory bacteria in the intestines; and the diet rich in plant foods is related to the intestinal bacteria with anti-inflammatory effects.
Therefore, adjusting your diet may help relieve inflammation in the body.
The researchers observed these patterns in all study participants, indicating that there is overlap in diet and gut microbiome information between healthy people and patients with inflammatory bowel disease or irritable bowel syndrome.
However, the researchers said that this is an observational study, so it is not yet possible to determine cause and effect, nor is it clear how long it takes for gut bacteria to respond to dietary changes.
But the researchers believe that despite these limitations, they can still derive dietary patterns related to known bacteria and functions to infer the protective and anti-inflammatory effects of the intestinal mucosa.
In patients with Crohn’s disease, ulcerative colitis, irritable bowel syndrome and the general population, the response of the intestinal flora to diet may also be related to other diseases, among which inflammation, changes in intestinal flora and nutrition are common clue.
Link to the paper: https://gut.
bmj.
com/content/early/2021/03/08/gutjnl-2020-322670 2020 Hot Article Selection 1.
The cup is ready! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the lethal changes do not occur in the brain, but in the intestines.
.
.
9.
The super large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight and restored the old brain to a young state.
.
.
Different eating habits create different intestinal microbiomes (i.
e.
intestinal flora).
As we all know, this intestinal ecosystem called the "second brain" is closely related to various human diseases, such as cancer, cardiovascular disease, type 2 diabetes, obesity and hypertension, as well as Alzheimer's and mental diseases.
.
In other words, the gut microbiome directly affects the balance of pro-inflammatory and anti-inflammatory responses in the intestine.
Recently, in a study published in "Gut", a research team led by the University of Groningen in the Netherlands revealed the interaction between diet, intestinal flora and its induction of intestinal inflammation.
Certain dietary patterns influence the inflammatory response in the intestine through pro-inflammatory or anti-inflammatory mechanisms.
Changing eating habits will help prevent intestinal inflammation in some chronic diseases.
It is known that the imbalance of the intestinal flora is related to more and more inflammatory diseases.
In addition to the local immune response, it also affects the systemic immune response and is related to more and more immune-mediated inflammatory diseases, including diabetes and arthritis.
And systemic lupus erythematosus.
However, it is still unclear whether specific foods or eating patterns will affect the composition of the gut microbiome, leading to inflammation in the gut.
To find out, the researchers looked at the interaction between the daily diet, gut microbiome, and gut inflammation of 1,425 participants.
Including 205 people with Crohn's disease (CD), 331 people with ulcerative colitis (UC), 223 people with irritable bowel syndrome (IBS), and 871 healthy individuals.
Each participant provided a stool sample for metagenomic sequencing and inflammatory marker testing.
They also filled out a food frequency questionnaire to quantify the average daily nutrient intake.
The researchers aggregated their diets into 25 patterns (see picture below).
After analysis, the researchers determined 38 associations between eating patterns and specific flora.
In addition, in a meta-analysis of healthy individuals with Crohn’s disease, ulcerative colitis, and irritable bowel syndrome, 61 foods and nutrients are related to 61 bacteria and 249 metabolic processes.
Researchers have found that processed foods and animal-derived foods are always associated with relatively high abundance of "opportunistic" bacteria (enemy bacteria) species, including Firmicutes and certain bacteria of the genus Ruminococcus (Ruminococcus sp.
.
), they are all involved in pro-inflammatory activities.
On the other hand, plant foods such as nuts, fruits, vegetables, and grains are related to "friendly" bacterial species, such as Faecalibacterium sp.
These beneficial bacteria can produce short-chain fatty acids (SCFA), which can ferment fiber and pectin into ethyl acetate.
Salt and butyrate have anti-inflammatory and protect the integrity of intestinal cells.
Coffee intake is also associated with higher abundance of Oscillibacter and increased glycolytic pathways, while edible cheese and yogurt and other fermented dairy products have been shown to be closely related to the abundance of lactic acid bacteria, butanediol and peptidoglycan synthesis Related.
The food groups of bread, beans, fish, and nuts are consistently associated with the relative abundance of "opportunistic" bacteria and lower pro-inflammatory activity.
The fast food group diet consisting of meat, French fries, mayonnaise, and soft drinks was associated with "enemy bacteria" among all study participants, such as Clostridium, Coprobacillus and Lachnospiraceae ).
In the absence of cellulose, these bacteria will turn to the mucus layer of the intestine for food, causing the integrity of the intestine to be eroded.
The colonic mucus layer serves as a barrier to isolate the intestinal contents and epithelial cells, and is also the first barrier.
Its structural and functional integrity play a very important role in the health of the human body.
Long-term intake of alcohol and sugar is associated with a higher quinone synthesis pathway, which is consistent with the increase in quinone synthesis in the intestinal tract of patients with inflammatory bowel disease (IBD).
To sum up, the large intake of animal-derived foods, processed meats, alcohol and sugar is related to the pro-inflammatory bacteria in the intestines; and the diet rich in plant foods is related to the intestinal bacteria with anti-inflammatory effects.
Therefore, adjusting your diet may help relieve inflammation in the body.
The researchers observed these patterns in all study participants, indicating that there is overlap in diet and gut microbiome information between healthy people and patients with inflammatory bowel disease or irritable bowel syndrome.
However, the researchers said that this is an observational study, so it is not yet possible to determine cause and effect, nor is it clear how long it takes for gut bacteria to respond to dietary changes.
But the researchers believe that despite these limitations, they can still derive dietary patterns related to known bacteria and functions to infer the protective and anti-inflammatory effects of the intestinal mucosa.
In patients with Crohn’s disease, ulcerative colitis, irritable bowel syndrome and the general population, the response of the intestinal flora to diet may also be related to other diseases, among which inflammation, changes in intestinal flora and nutrition are common clue.
Link to the paper: https://gut.
bmj.
com/content/early/2021/03/08/gutjnl-2020-322670 2020 Hot Article Selection 1.
The cup is ready! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the lethal changes do not occur in the brain, but in the intestines.
.
.
9.
The super large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight and restored the old brain to a young state.
.
.
