He Shudong's team from Hefei University of Technology: Research progress in the identification of food protein allergen epitopes

Original title: TRENDS FOOD SCI TECH | He Shudong's team from Hefei University of Technology: Research progress of food protein allergen epitope identification technology

About 8% of children and 5% of adults worldwide are food allergies.

In this context, in order to understand the sequence and structure of allergen epitopes, develop new hypoallergenic foods, and promote the development of food allergy prevention, diagnosis and treatment methods, He Shudong’s team from the School of Food and Bioengineering of Hefei University of Technology A review of the latest research progress in protein allergen epitope identification technology, the article is titled Advances in epitope mapping technologies for food protein allergens: A review, published in Trends in Food Science & Technology, Volume 107 in 2021 (article link: https: //doi.

Fig.

Using the specific interaction between phage-displayed antigen polypeptides and antibodies, epitopes of allergens can be screened out.

Compared with peptide scanning technology, phage display technique has the advantages of small workload, convenient operation, large peptide library, high screening efficiency, economical and practical, and the ability to identify key amino acids that bind to antibodies.