He Yun: global natural medicine research trend and hotspot

Professor He Yun has been engaged in the research of bioactive natural products for nearly 20 years and is a senior expert in new drug research and development On September 24-25, under the guidance of China Pharmaceutical University, research center for the development of contemporary Chinese medicine, Chongqing Economic and Information Commission, sponsored by the elite club of pharmaceutical intelligence and hosted by the website of pharmaceutical intelligence, Professor He Yun will attend the 2016 China Pharmaceutical R & D Innovation Summit and the conference of the top 100 research and development strength of pharmaceutical enterprises as a specially invited expert to give you a wonderful speech He will comprehensively elaborate the significance of drug research and development based on natural products, and select some cases to analyze the research process from natural products to drugs on the market, to show the role of synthetic chemistry, drug chemistry and drug design in the research and development of natural products He Yun, Ph.D supervisor, expert of national thousand talents plan, distinguished professor of Chongqing University School of pharmacy, director of Chongqing University Innovation drug research center, dark suit coat, ordinary light blue shirt, wearing a pair of thin frame glasses, slightly bending up the corner of the eye, smiling with high spirits Seeing he Yun for the first time, he thought to himself: an easy person with wisdom, feelings and fun should be such a determined and dignified appearance! Because of his strong interest in chemistry, he Yun chose chemistry as his undergraduate course He has been engaged in the research of bioactive natural products since he started from Professor Huang naizheng, academician of the Chinese Academy of Sciences in 1988 It has been 28 years since then This is the direction of his efforts and the fun he has been pursuing He went to the United States to study in 1990, where he studied with two world-renowned organic chemists, K C Nicolaou and Richard C Larock, and received a Ph.D from the Scripps Institute, the top biomedical research institute in the United States After graduation, he Yun has more than 15 years of rich practical experience in new drug research and development, strategic planning and senior scientific research management in Abbott, Novartis and Roche, one of the top 500 pharmaceutical companies in the world He has led and participated in more than 30 innovative drug research and development projects, contributing 8 class 1.1 clinical new drugs (i, Phase II and phase III) and more than 10 preclinical drugs; once served as president of China US biotechnology and Pharmaceutical Association, director of Baihua Association, visiting professor of Peking University and Shanghai Institute of pharmacy, Chinese Academy of Sciences, as the second leader of Baonuo technology company, led the team to successfully transfer the company to PPD, a US listed company Over the past 20 years, he Yun has been engaged in the research and industrialization of innovative drugs for cancer, antiviral, diabetes and metabolic diseases As an inventor, he has applied for more than 100 patents, more than 30 patents have been authorized by the United States, and published more than 70 research papers in world-class academic journals While establishing Chongqing Liangjiang pharmaceutical R & D Center Co., Ltd., Chongqing Liujiang pharmaceutical science and Technology Co., Ltd., Chongqing Huazhi pharmaceutical testing technology Co., Ltd and other enterprises, he also led the team to establish the Pharmaceutical College of Chongqing University Now, he is the director, distinguished professor, doctoral supervisor of the school of pharmacy and innovative drug center of Chongqing University, expert of Chongqing hundred talents plan and national thousand talents plan "Bioactive natural products have always been an important source of new drugs Nearly half of the new drugs on the market in the world are natural products, natural product analogues or derivatives based on the pharmacophore of natural products." He Yun said frankly, "in the 1990s, with the emergence of combinatorial chemistry and high-throughput screening, he and his team found a large number of promising new compounds with this technology, and made them the leading compounds through structural optimization, on the basis of which, they launched the final drugs on the market." "Over the past decade, most biopharmaceutical companies have either eliminated natural product development or reduced their share of drug development." He Yun said, "however, with the production rate of combinatorial chemistry and high-throughput screening gradually reduced, the difficulty of new drug approval increased, and the cost of drug research and development continued to rise, people began to realize that the novel skeleton, new mechanism of action and excellent biological activity of natural products still occupy an important proportion in drug research and development, and drug research and development based on natural products is on the rise Potential " "Drug development based on natural products still faces many challenges, such as complex molecular structure, difficult synthesis and processing, poor physical and chemical properties and pharmacokinetic properties." Professor He Yun pointed out On September 24-25, under the guidance of China Pharmaceutical University, research center for the development of contemporary Chinese medicine, Chongqing Economic and Information Technology Commission, hosted by the elite club of pharmaceutical intelligence and hosted by the website of pharmaceutical intelligence, "2016 China Pharmaceutical R & D Innovation Summit and conference of the top 100 research and development strength of pharmaceutical enterprises" Professor He Yun will comprehensively explain the significance of drug research and development based on natural products, and select some cases to analyze the research process from natural products to drugs on the market, to show the role of synthetic chemistry, pharmaceutical chemistry and drug design in the research and development of natural products 2016 China Pharmaceutical R & D innovation summit opened in September in Chongqing We are in the beautiful mountain city of Chongqing Where are you? Summit registration interface link: http://news.yaozh.com/zhuanti/detail.html? Id = 4