"Heavy" probiotic science research top ten hot spots " authoritative release!

years, scholars at home and abroad have carried out a lot of scientific experimental research on the resources, efficacy, mechanism of action and safety of probiotics. The rise and development of new disciplines and technologies, such as system biology, synthetic biology and multi-group science, provide new ideas and opportunities for the development of probiotic science and technology and industry. Many new academic views and achievements have emerged in the field of probiotic research.At the time of the preparation of the National Medium- and Long-Term Science and Technology Development Plan and the 14th Five-Year Plan for 2021-2035, in order to focus on the current research hotspots of probiotic science, the research field of probiotics urgently needs to crack the key common problems. The Probiotic Branch of the Food Science and Technology Society organized relevant scientific research workers based on literature measurement, combined with the scientific and technological community and industry related scientific and technological workers on the research progress of probiotics, condensed the formation of "the top ten hot spots of probiotic science research", and officially released at the 15th International Symposium on Probiotics and Health.
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. Consultant:Chen Wei
Fellow of the Chinese Academy of Engineering, Jiangnan University Rennational Government
Fellow of the Chinese Academy of Engineering, Co-Writer of china Agricultural University Co-Writer:Zhang Guohua
Shanxi University Saiqi Xiao
Jiangnan University Ehuaxi
China Ocean University Sun Zhihong
Inner Mongolia Agricultural University Zhao Liang
China Agricultural UniversityChen Wei
China Food Science and Technology Society Rojiang Yu
China Food Science and Technology Societyparticipated in the discussion and review experts (in order of chinese strokes by last name): yun comrade
Inner Mongolia Yili Industrial Group Co., Ltd. Shi Hanping.
Beijing Century Temple Hospital, affiliated with Capital Medical University, . Hino Jin
Reuters Ledo (China) Investment Co., Ltd. Ju Hong
Shijiazhuang Junlebao Dairy Co., Ltd. Yang Ruiyu
Institute of Microbiological Epidemiology, Military Academy of Sciences Institute of Military Medicine He Guoqing
Zhejiang UniversityZhang Lanwei
China Ocean UniversityZhang Ping
Inner Mongolia Agricultural University Jin Su
DuPont Nutrition and Biotechnology Yao Su
China Food Fermentation Industry Research Institute Xu Jin
National Food Safety Risk Assessment Center Dong Ying
Jiangsu UniversityHot spot 1probiotics and digestive health
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. The human digestive tract is distributed with about 10 trillion microorganisms, and the micro-ecological balance of the digestive tract affects the health of the body. Probiotics can prevent and control oral diseases, gastritis, stomach ulcers, irritable bowel syndrome and inflammatory bowel disease by regulating the micro-ecological balance of the digestive tract, inhibiting the growth and adhesion of pathogenic bacteria, and reducing inflammatory response. However, the mechanism, clinical effect and population difference of different probiotic strains still need to be confirmed by evidence-based medicine. Anaerobic intestinal chips and intestinal microbial collection capsules can provide new methods for studying the mechanism of probiotics in the intestines.
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2probiotics and immunomodulationimmunity is the cornerstone of human health, once its dysfunction, the body may produce allergies, tumors or viral infections and other health problems. The intestine is known as the body's largest "immune organ" and is an important place for probiotics to function. The research shows that probiotics can regulate the body's immune function by enhancing the function of the intestinal mucosa barrier, inhibiting the growth and adhesion of pathogenic bacteria, regulating the activity of immune cells and promoting the production of immune factors. However, the immunomodulation effect of probiotics is specific to strains, and the screening, immune regulation effect and mechanism of specific antigen probiotic strains need to be studied in depth. Studying the regulation mechanism of probiotics on the body's immune function through immunology, establishing the molecular library related to immunity, analyzing the functional components of the action and its targets, will provide a new way of thinking to reveal the role of probiotics in the body's immune regulation.
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hot spot 3 probiotics and metabolic syndrome In recent years, the incidence of metabolic syndrome characterized by metabolic disorders such as type II diabetes, hyperlipidemia and hypertension has been increasing, which has seriously affected public health. Intestinal microbiome disorder is one of the factors leading to metabolic syndrome, and probiotics represented by Lactobacillus and Bifidobacteria can regulate the micro-ecological balance of the intestine and regulate the metabolism of the body to reshape the intestinal environment, thus alleviating the occurrence and development of metabolic syndrome. At present, most studies focus on the effect of probiotics in preventing and treating metabolic diseases, but the mechanism of probiotics is insufficiently explored. The main reasons are due to the complexity of the etiology of various metabolic diseases, the differences in probiotic effects of different probiotic strains, and the different mechanisms of probiotics to alleviate metabolic syndrome. , the future still needs to carry out personalized probiotic screening and clinical verification for all kinds of metabolic syndromes, in-depth exploration of the role of probiotics to regulate metabolic syndrome and its mechanisms.
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probiotics and intestinal-X-axis 90% of serotonin in the human body is produced in the intestines. Intestinal microbes regulate host mood and behavior by affecting the intestinal-brain axis through path pathlands involving nerves, immune systems, and endocrine. In addition, enterobacteria has complex interoperability with organs and tissues such as the lungs, liver, kidneys, muscles and bones (the "intestinal-X axis"). The interoperability of the intestinal-X axis can be used as a new target for drug development, and probiotics can regulate the body's tissues, organ function and behavior by involving intestinal nerves, immune system, endocrine signals, etc., which can benefit the host's health. that although probiotics have become an effective means of regulating the micro-ecology of the gut and other organs, their biological mechanisms are still unclear. Therefore, future research should focus on the use of multi-histological techniques to highlight the specific "contribution" of probiotics, taking into account strain specificity and dosage, in order to explore its mechanism of action in greater depth.
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of precision probiotics screening and functional prediction probiotic efficacy evaluation should focus on strain levels, this view has become a wide consensus in the scientific and technological community. Probiotic efficacy is influenced by its habitat source, host diet, age, gender and other factors, and the precise screening of probiotics requires attention to personalized differences. Traditional fermented food and the intestines of healthy people in different regions of China contain a large number of probiotic strains, which is a valuable microbial resource for screening specific functional probiotics. Using bottom-up strain screening strategies based on ideotypes, genotypes and targets, combining multi-group technology, establishing probiotic rapid and accurate screening methods and functional prediction techniques at multiple scales, developing personalized and functional probiotic strains for different populations, giving safe and efficient personalized probiotic interventions, balancing the micro-ecological environment of the human body, achieving effective prevention of disease occurrence and development, and maintaining the health of the body.
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6 probiotics and diet mutual the interoperability of diet and gut bacteria has become a new target for human health regulation. The effects of different dietary patterns and food types on probiotics varied. Supplementing probiotics is an important means to regulate the intestinal bacteria. Probiotics can transform the ingredients in the diet to form new substances that are easier to absorb and more active, and dietary groups can promote the growth of specific probiotics. The combined consumption of the two can promote the growth of probiotics and dietary metabolism, better play a health effect. Functional dietary supplements, represented by dietary fiber, medicinal ogenetic plant extracts, etc., have a regulatory effect on the growth and function of probiotics, regulate flora disorders, protect the intestinal barrier, and relieve inflammation and metabolic syndrome. The human genotype and intestinal bacteria jointly determine the ideotype, and the mechanism between the "food-probiotic-metabolism" path and the human body needs further study.
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hot spot 7 probiotics and after-life elements / probiotics after-life metaphysics / probiotics after inactivation treatment can still play a role in metabolites or bacterial components, with the role of regulating the body's immunity, protecting the intestinal barrier and regulating the intestinal microbiome and other health functions. The research shows that the after-birth meta/class is more sustainable and stable to the gastrointestinal physiological environment and production and processing conditions, and has a better application prospect. present, limited by the technical means of research, most studies focus only on proteins, polysaccharides and other active substances, and do not carry out higher-resolution effect substance identification. The separation identification and functional evaluation of probiotic metabolites are the key to the marketization of after-life/classes.
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8 Probiotics and Emerging Technologies With the continuous development of basic disciplines, more emerging technologies have been introduced into probiotic research. Techniques such as genome-wide sequencing, single-cell sequencing, macrogenomics, transcriptomics, proteomics and metabolomics can reveal in depth the genetic information, evolutionary relationships, physiological characteristics, metabolic networks, functional mechanisms and industrial application potential of strains; in the industrialization of applications, more emerging technologies are used in probiotic burying, drying, delivery, testing and so on. Such as the use of new wall materials to achieve layer-by-layer packaging and targeted intestinal delivery of strains, based on fluid cytometics to achieve rapid real-time detection of live bacteria. In the future, more cutting-edge technologies will be applied to the probiotic industry, further enhancing the industry's scientific and technological competitiveness.
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hot spot 9 a new generation of probiotics and probiotics new mechanism the new generation of probiotics is based on the human gut-specific symbox development, which plays an important role in intestinal bacteri group balance and host physiological function. Strains such as Akkermansia muciniphila have the potential to improve the intestinal mucosa barrier and metabolic diseases, and are candidates for a new generation of probiotics, and clinical studies of strains accumulate basic data for their drug applications. In the future, functional and safety assessments of new probiotics will be needed, as well as applied technology research and regulatory construction to promote the application of new generation probiotics. With the further study of the relationship between intestinal bacteriology and host health, the target points of intestinal bacteri groups closely related to host physiological function are gradually clarified. The role of probiotics on the metabolic network of intestinal bacteri groups, and the intervention of probiotics on host physiology and disease by regulating intestinal molecular targets, has become a new hot spot in the study of probiotic mechanism.
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hot spot 10 probiotics and food safety probiotics generally come from traditional fermented food or healthy human intestine, in the safety evaluation or functional evaluation of the host there is no obvious risk. The strains in China's List of Bacteria That Can Be Used for Food can be used directly in ordinary foods. At present, the widely used probiotics are Lactobacillus and Bifidobacteria, which have a long history of consumption, clear sources and high safety. However, probiotic interventions are not recommended for immunodeficiency and critically ill patients in clinical practice. Systematic safety evaluation is needed for new strains of probiotics and new generations of probiotics to clarify the safety of strains. At the same time, specific safety assessments for different strains, as well as specific populations or individuals, are the future direction of probiotic food safety evaluation. . The above ten hot spots, based on the search of more than 15,000 related scientific and technological literature, and combined with the Chinese Food Science and Technology Association Probiotic Branch in 2020 collected from 149 units of 720 probiotic industry research questionnaire analysis and the future development of probiotic industry related recommendations, by the probiotic field nearly 20 authoritative experts to participate in the completion. Finally, in the form of "Top Ten Hot Spots of Probiotic Science Research and Industry Development Proposals", it was launched online on August 18, 2020 in the China Food Journal. China Food Science and Technology Society