[heavyweight] new progress of vaccine incident: Changsheng issued 4 consecutive announcements on two days, revealing that the company was hit 5 times; the drug regulatory bureau responded to the vaccine in Wuhan; Shandong CDC committed suicide? ...

Li Keqiang listened to the progress report on the investigation of the Changsheng vaccine incident On July 30, Premier Li Keqiang presided over the executive meeting of the State Council, listened to the progress report on the investigation of the illegal production of rabies vaccine by Jilin Changchun Changsheng company, and demanded that the investigation and treatment be strictly carried out and a long-term mechanism for ensuring the safety of drug use be established It was proposed that participants should be prohibited from engaging in the pharmaceutical industry for life Changsheng issued 4 consecutive reports on two days, which revealed that the company suffered a 5-hit On July 30, the involved company, Changsheng biology, issued three consecutive announcements (see Figure 1, figure 2 and figure 3) Today, another announcement about the abnormal fluctuation of the company's stock was issued (see Figure 4) According to the content, Changsheng biology revealed the company's current heavy losses and difficulties from five aspects, such as the overall production suspension of products, the freezing of bank accounts, the difficulty of capital turnover, and the suspension of projects Fig 1, Fig 2, Fig 3, FIG 4 num1 Changsheng bio's products were all shut down and its normal business activities could not be resumed within three months On July 15, 2018, the website of the State Drug Administration disclosed the notice on illegal production of freeze-dried human rabies vaccine by Changchun Changsheng Bio Technology Co., Ltd (No 60, 2018) Jilin food and drug administration is required to withdraw the GMP certificate (Certificate No.: jl20180024) of the enterprise and order to stop the production of rabies vaccine On July 18, 2018, Changchun Changsheng Biotechnology Co., Ltd (hereinafter referred to as "Changchun Changsheng"), a wholly-owned subsidiary of the company, received the decision on administrative penalty from Jilin food and drug administration Decision: 1 To confiscate 186 pieces of "adsorptive acellular pertussis combined vaccine" (batch No.: 201605014-01) in stock; 2 To confiscate 859000 yuan of illegal income 3 Impose a fine of 2584047.60 yuan for three times the value of illegally produced drugs The total amount of fines and confiscations is 3442887.60 yuan At present, in addition to baibaibaipo combined vaccine and freeze-dried Purified Hamster Kidney Cell Rabies Vaccine products are ordered to stop production, the company has decided to completely stop production of other products of the company through research, and the above production workshops have conducted self-examination and self-correction during the period of stop production, and carried out comprehensive and thorough rectification And the time of resumption is uncertain The company's production and operation activities are seriously affected and it is expected that they will not return to normal within three months Num2 Trio of case progress, the persons involved in the case are reviewed according to law, detained forcibly, and submitted for arrest At 15:00 p.m on July 23, 2018, Changchun New Area Public Security Bureau, in accordance with the letter of transfer of suspected criminal cases issued by Jilin food and drug administration, filed and investigated the suspected illegal criminal cases of freeze-dried human rabies vaccine produced by Changchun Changsheng, and brought the chairman of the company, three senior executives and two middle-level personnel of the company who were mainly involved to the public security organ for examination according to law On the evening of July 24, 2018, Changchun New Area Public Security Bureau reported that 15 people involved in the case, such as chairman Changchun Changsheng, were detained by Changchun high tech Zone Public Security Bureau according to law because they were suspected of criminal crimes Among the above 15 people taken away by the public security organs are two directors of the company, including Gao Junfang (Chairman), Zhang Jing (director), Zhang Youkui, Liu Jingye, Jiang Qianghua and Zhao Zhiwei On the evening of July 29, 2018, Changchun New Area Public Security Bureau reported that according to Article 79 of the criminal procedure law of the people's Republic of China, Changchun New Area Public Security Bureau applied to the inspection authority for approval of arrest of 18 suspects, including Gao Junfang, chairman of Changchun Changsheng Biotechnology Co., Ltd., for suspected production and sale of substandard drugs Two directors of the company are among the above 18 people who have been requested by the public security organ for approval of arrest, including Gao Junfang (Chairman of the board), Zhang Jing (director), Zhang Youkui, Liu Jingye, Jiang Qianghua and Zhao Zhiwei Num3 The company's stock fluctuated abnormally, and its abbreviation was changed to "St Changsheng" company's stock trading was suspended on July 25, 2018, and resumed on July 26, 2018 In addition, the company's stock has been subject to other risk warnings since the opening of the market on July 26, 2018 The company's stock abbreviation has been changed from "Changsheng biology" to "St Changsheng", the company's stock code is still "002680", and the company's stock trading day limit is 5% Within three consecutive trading days (July 26, 2018, July 27, 2018 and July 30, 2018), the closing price of Changsheng bio stock has declined by 12% in total According to the relevant provisions of Shenzhen Stock Exchange's stock trading rules, the company's stock trading belongs to abnormal fluctuation Num4.34 bank accounts and fund-raising accounts were frozen Changsheng biology disclosed the announcement on freezing bank accounts of the company and its subsidiaries (Announcement No.: 2018-080) on relevant platforms on July 27, 2018 Said: the company and Changchun Changsheng's main bank accounts and fund-raising accounts have been frozen As of July 30, 34 bank accounts under the name of the company and all subsidiaries have been frozen, and the freezing of the above accounts directly causes the company to be unable to pay the project funds raised and the project funds of the industrial park of the subsidiaries Now, the construction of many projects, such as the technical transformation of the varicella vaccine rabies vaccine workshop, the research and development of vaccine products, has also been suspended, and the restart time of the project is temporarily uncertain Num5 The company's capital chain is tight, and many projects suspend the investment of long-term biology relying on fund-raising, including varicella vaccine rabies vaccine workshop technology transformation project, vaccine product research and development project, marketing network construction project, information construction project, payment of intermediary fees, supplement of working capital, etc The project of Changsheng Yungang biopharmaceutical Industrial Park, a subsidiary of the company, has a total planned investment of 1.2 billion yuan, including 1.12 billion yuan of fixed assets investment and 80 million yuan of initial working capital, which is self raised With the freezing of the company's main bank accounts and raised capital accounts and problems in capital operation, the suspension of the above projects will have a significant impact on the project's committed completion period and subsequent production In addition to Changsheng, the State Food and drug administration responded positively to the vaccine issue in Wuhan The titer index of DPT vaccine of both Changsheng biology and Wuhan biology was unqualified On July 31, a spokesperson from the State Food and Drug Administration introduced relevant information on the pertussis vaccine of Wuhan Institute of Biological Products Co., Ltd (hereinafter referred to as "Wuhan biology") 1 In 2017, pertussis titer index of pertussis vaccine with batch number of 201607050-2 produced by Wuhan biological Co., Ltd did not meet the standard, which was mainly caused by the short-term failure of the subpackage equipment, resulting in the uneven suspension of the products to be subpackaged, which was accidental; 2 A spokesman of the State Food and Drug Administration mentioned that in March 2018, the former State Food and Drug Administration sent another inspection team to Wuhan Hansheng Through inspection on the rectification of WBD vaccine, the enterprise has completed the rectification, which is in line with the GMP; 3 The spokesman of the State Food and drug administration responded that the punishment measures for this incident were: on May 29, 2018, Wuhan food and Drug Administration confiscated the illegal income and punished Wuhan Bio in accordance with the relevant laws and regulations of the drug administration law Decision on administrative penalty Vaccine related suicides in Shandong CDC? Today, a reporter learned that song Lizhi, director of the Institute of immunology of the center for Disease Control and prevention of Shandong Province, tried to commit suicide by injecting excessive insulin At present, he is being rescued in the ICU of the Shandong Provincial Hospital, and he is not out of danger It is understood that song Lizhi is one of the five members of the bid evaluation committee of DPT vaccine won by Changsheng biology Information source: Announcement and online public information of Changsheng Biotechnology Co., Ltd