Hengrui medicine for angina pectoris has been approved for marketing in Germany and the Netherlands

On the evening of June 18, Hengrui pharmaceutical announced that cadiasun Pharma GmbH, a subsidiary of the company, had recently received approval letters from the German Federal Institute of drugs and medical devices and the Dutch drug evaluation commission, approving the listing application of the company's hydrogen sulfate ivabradine tablet for angina pectoris treatment in Germany and the Netherlands On December 15, 2017, the listing application submitted by cadiasun Pharma GmbH to the German Federal Institute of drugs and medical devices and the Dutch drug evaluation committee was accepted Ivabradine sulfate is mainly used in the treatment of chronic stable angina pectoris with normal sinus rhythm, which is contraindicated or intolerable to β receptor blockers It plays a role by selectively inhibiting the IF channel responsible for controlling the automatic depolarization of sinoatrial node and regulating heart rate Ivabradine tablets were initially made into tablets in the form of hydrochloride, developed by Servier Laboratories Limited (Servier), with the drug name of ivabradine hydrochloride film coated tablets and the trade names of correntor and procoralan The drug was first listed in Europe in 2005, and now it has been listed in China, the United States and Europe Upon enquiry, ivabradine apharm, ivabradine accord and other similar products in Europe have been approved At present, only the ivabradine hydrochloride tablets of Les Laboratoires Servier (Servier) are on the market in China Our company has developed the ivabradine sulfate with single crystal and stable crystal form, and there is no ivabradine sulfate tablet for sale at home and abroad According to the IMS database, the global sales volume of ivabradine hydrochloride tablets in 2018 is about $320 million, the sales volume in Europe is about $200 million, and the sales volume in China is about $2.62 million Up to now, the R & D cost of the product project has been about 47.9 million yuan.