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A new, powerful "game-changing" antibiotic could save millions of lives around the world from drug-resistant superbugs, according to new research from the University of Liverpool
.
The new antibiotic is a simplified synthetic version of the compound Teixobactin, which kills bacteria without damaging mammalian tissue
.
In experiments, the researchers used the compound to successfully eradicate the superbug methicillin-resistant Staphylococcus aureus (MRSA) in mice
.
MRSA is a common clinically virulent bacterium that has become resistant to widely used antibiotics
.
MRSATeixobactin was first hailed as a "game-changing" antibiotic in 2015, but the new study developed a simplified synthetic version of the compound
.
The new version of the compound can be stored at room temperature, making it much easier for future drugs to be distributed globally
.
More than 1.
2 million people died from antibiotic-resistant bacterial infections in 2019, according to a January 2021 study in The Lancet
.
Global health officials have repeatedly warned that the misuse and overuse of antibiotics has fueled the evolution of microbes into "superbugs," leading to a constant threat from drug-resistant bacteria and other pathogenic microorganisms
.
In the future, patients may be able to treat life-threatening systemic drug-resistant bacterial infections with a single daily dose of Teixobactin, the team said
.
They also say that by replacing certain amino acids on the molecule with cheaper alternatives, the cost of pharmaceuticals has been reduced by more than 2,000 times
.
The researchers hope that the new results will pave the way for large-scale, inexpensive production of drugs
.
Lead researcher on the study, Dr Ishwar Singh, said the breakthrough was an important step towards addressing the current growing crisis of antibiotic resistance
.
.
The new antibiotic is a simplified synthetic version of the compound Teixobactin, which kills bacteria without damaging mammalian tissue
.
In experiments, the researchers used the compound to successfully eradicate the superbug methicillin-resistant Staphylococcus aureus (MRSA) in mice
.
MRSA is a common clinically virulent bacterium that has become resistant to widely used antibiotics
.
MRSATeixobactin was first hailed as a "game-changing" antibiotic in 2015, but the new study developed a simplified synthetic version of the compound
.
The new version of the compound can be stored at room temperature, making it much easier for future drugs to be distributed globally
.
More than 1.
2 million people died from antibiotic-resistant bacterial infections in 2019, according to a January 2021 study in The Lancet
.
Global health officials have repeatedly warned that the misuse and overuse of antibiotics has fueled the evolution of microbes into "superbugs," leading to a constant threat from drug-resistant bacteria and other pathogenic microorganisms
.
In the future, patients may be able to treat life-threatening systemic drug-resistant bacterial infections with a single daily dose of Teixobactin, the team said
.
They also say that by replacing certain amino acids on the molecule with cheaper alternatives, the cost of pharmaceuticals has been reduced by more than 2,000 times
.
The researchers hope that the new results will pave the way for large-scale, inexpensive production of drugs
.
Lead researcher on the study, Dr Ishwar Singh, said the breakthrough was an important step towards addressing the current growing crisis of antibiotic resistance
.
