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High blood pressure variability in middle-aged and elderly people can significantly increase cognitive impairment

 Last Update: 2021-06-16
 Source: Internet
 Author: User

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High blood pressure variability in middle-aged and elderly people can significantly increase cognitive impairment

High blood pressure variability in middle-aged and elderly people can significantly increase cognitive impairment.

Clinical cohort study deciphering the relationship between blood pressure and cognitive impairment image courtesy of Yu Jintai

Professor Yu Jintai from the Department of Neurology, Huashan Hospital Affiliated to Fudan University, and Professor Tan Lan from the Department of Neurology, Qingdao Municipal Hospital, Affiliated to Qingdao University, conducted a large clinical cohort study of 1546 cases lasting 5 years, revealing the relationship between different blood pressure characteristics and cognitive impairment , And found for the first time that the pathological changes of tau protein in the brain may be a key link in the impact of blood pressure on cognitive impairment (such as the two main causes of Alzheimer’s disease are the presence of senile plaques and neurofibrillary tangles in the brain, the former is caused by β-amyloid is formed, and the latter is mainly formed by the accumulation of pathological tau protein), and high blood pressure variability in middle-aged and old age can significantly increase cognitive impairment
.

Related research results were recently published in the "Journal of Alzheimer's Disease and Dementia"

It is reported that both hypertension and dementia have become important public health problems in today's society
.

However, the relationship between blood pressure and cognitive impairment in the world medical community has not been completely clear

To this end, the Yujintai team established a large-scale cognitive impairment clinical research database and biological sample bank based on the CABLE cohort (Chinese Alzheimer's Disease Biomarker and Lifestyle Research), which includes participants Daily blood pressure data, cognitive assessment data, and biomarker levels related to Alzheimer's disease (AD) pathology
.

For the first time, the research team included and explored a variety of different blood pressure characteristics (including diagnosis of hypertension, systolic blood pressure, diastolic blood pressure, pulse pressure, mean arterial pressure, and blood pressure variability), cognitive impairment, and the pathological changes of Alzheimer’s disease.

Further studies have confirmed that the pathological changes of tau protein at the core of Alzheimer's disease may be a key link in the impact of blood pressure on cognitive impairment, and its effect can be as high as 30%
.

This discovery provides important clues for revealing the specific mechanism by which blood pressure affects cognitive impairment

Yu Jintai said that the results of this study revealed in detail the association between different blood pressure characteristics and the risk of cognitive impairment (including Alzheimer's disease) through a clinical cohort study for the first time, and revealed its underlying biological mechanism
.

The discovery of this mechanism suggests that targeting tau-related pathologies may become an important target for preventing cognitive impairment caused by blood pressure