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Juvenile abnormal visual experience (such as anisometropia or strabismus) can lead to amblyopia, severely impairing visual acuity, color and stereo vision, eye movement and attention and other visual functions, and the incidence is about 3%
3T/7T fMRI reveals the damage and compensatory mechanism of the outer geniculate body-V1 small cell pathway and cortex-superior colliculus pathway in amblyopia ( Wen and Wang et al.
Based on the response characteristics of non-human primate external geniculate body neurons, researchers designed M and P stimulations that selectively activate the large cell (magnocellular, M) and small cell (parvocellular, P) pathways (as shown in the figure), Presented to the amblyopic eye (AE), the contralateral eye (FE) and the normal eye (NE) of healthy controls for monocular amblyopia patients
This study revealed the abnormal function of the outer geniculate body-V1 small cell pathway and the cortex-superior colliculus pathway in adults with amblyopia, challenging the traditional view that amblyopia mainly affects the visual cortex
The paper was published in " Cell Reports " on December 14, 2021
Article link: https://doi.
High-resolution fMRI can break through the bottleneck that traditional fMRI is limited to the brain level, and image the fine mesoscopic functional units of the human brain in the whole brain.
High-resolution fMRI atlas of the human brain visual system
references:
Wen, W.
Shao, X.
de Hollander, G.
Zhang, J.
Liu, C.
Qian, Y.
Ge, Y.
Yu, Q.
Zhang, P.
Zhang, P.
* , Zhou, H.
, Wen, W.
, & He, S.
* (2015).
Layer-specific response properties of the human lateral geniculate nucleus and superior colliculus.
NeuroImage , 111.
https://doi .
org/10.
1016/j.
neuroimage.
2015.
02.
025
(Contribution: Zhang Peng Research Group)
