Higher stability, greater expression, improved version of the new coronavirus hedgehog protein variant.

In developing the new coronary vaccine, most studies have focused on targeted prickly proteins, which are key to the virus entering and infecting human cells.
scientists have developed prickly protein variants such as S-2P to improve the vaccine's ability to produce immune responses and mass production.
these modified versions are not stable enough to be mass-produced in mammalian cells.
to overcome these problems, the team at the University of Texas at Austin carefully analyzed the structure of the hedgehog protein and studied the effects of various changes on the chemical properties of the protein.
they identified 100 structurally oriented prickly protein modification programs, identified 26 versions that improved protein expression and stability, and eventually created HexaPro, a variant containing six beneficial proline substitutes.
tests showed that HexaPro had an expression 9.8 times higher than the S-2P, could withstand temperatures of 55 degrees C for 30 minutes, could be stored at room temperature for 2 days, and remained stable during multiple freezing and thawing processes.
this means that the protein variant is not only easier to store and transport, but can also be mass produced.
that the original version of HexaPro, known as S-2P, has been used in a variety of new coronavirus candidate vaccines.
Compared to S-2P, HexaPro has the advantage of increasing the efficacy of DNA- or mRNA-based vaccines and expanding the unit-time production of sub-unit vaccines with actual viral proteins as antigens, making it possible to industrialize vaccine production, which will have a wide impact on the design of the next generation of coronavirus vaccines and greatly reduce public health pressures facing the world.
editor-in-chief circle and SARS virus, the new coronavirus also recognizes the human ACE2 protein through the hedgehog protein into human cells.
naturally, the new coronavirus prickly protein has become the research frontier and hot spot in this outbreak.
, scientists cracked the structure of the new coronavirus prickly protein.
, a team of researchers analyzed the complex structure of the ACE2 full-length protein binding domain with the new coronavirus prickly protein.
, scientists have successfully designed a new version of the new coronavirus prickly protein variant.
these studies will greatly advance the development of new coronavirus vaccines and drugs.
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