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Pictured: Professor Adrian Bracken from the School of Genetics and Microbiology at Trinity College Dublin led this landmark study
Source: Trinity College Dublin
Geneticists from Trinity College Dublin have discovered how a special gene mutation called H3K27M can lead to a devastating and incurable childhood cancer called diffuse midline glioma (DMG), and they are experimenting The model cell type was studied in the laboratory, and its effect of slowing down the growth of cancer cells was successfully reversed through targeted drugs
Their landmark work-just published in the leading international journal Nature Genetics, and supported by the World Cancer Research and Brain Tumor Charity-will be a crucial new understanding of the genetics of DMG progress The transformation into a very promising and targeted treatment method provides great hope for improving treatment in the future
Scientists are now calling for the immediate start of clinical trials to evaluate an approved class of drugs called "EZH2 inhibitors
Main findings and impact
This important work found:
How a special gene mutation called H3K27M causes DMG
How to target this oncogene with drugs that slow the growth of cancer cells
They also established a specific model cell line to evaluate further targeting DMG methods
He said: "We have taken a big step in the research of DMG tumors, and hope that these insights will help us design and implement precision oncology treatments for DMG patients in the future
"Ultimately, we hope that our work — and the work of others focused on this field — will lead to clinical treatments for this truly terrible disease, which can destroy families, and there are currently no treatment options
Pediatric glioma-a distressing and devastating cancer
Childhood gliomas like DMG are one of the most devastating childhood cancers
Dr.
Speaking of the importance of this work, Maeve Lowery, Professor of Translational Cancer Medicine at Trinity College and Academic Director of the Trinity St.
Dr.
Developing cancer treatments-why this research is different
In general, the development of effective cancer treatments take decades; in fact, scientists may take years to develop relevant cell types of model systems, so that they have the opportunity to "explore the mysteries of genes"
Such research can first help us understand how cancer works
Therefore, the scientists in this study have made great progress in the fight against DMG.
